UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 1 / Published : 2009-01

Order : 5, and page :22 - 27

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Original Article :

Difference of plasma interleukin-10 level in pulmonary tuberculosis patients and healthy nurses with pulmonary tuberculosis risk

Author :

  1. Endang Retnowati*1
  2. Soedarsono*2
  3. Ronny Sindunata*3
  1. Department of Clinical Pathology Airlangga University School of Medicine
  2. Department of Pulmonology Airlangga University School of Medicine
  3. Department of Clinical Pathology Airlangga University School of Medicine

Abstract :

Introduction: Tuberculosis is an emerging infectious disease. Indonesia is the third country with the most cases of tuberculosis in the world. Tuberculosis eradication program is only focused in case finding and treating tuberculosis patients. Health care workers are at risk of tuberculosis infection, but there is no examination yet for early detection of tuberculosis activity. To know the activity of tuberculosis, several examinations should be performed and one of them is IL-10. There is no IL-10 study yet in Indonesia, so a study about the difference of plasma IL-10 levels in lung tuberculosis patients and nurses at risk of lung tuberculosis is needed. Objective: to analyze the difference of plasma IL-10 of lung tuberculosis patients and nurses at risk of lung tuberculosis. Materials and methods : a cross sectional, observational analytical study of 10 nurses at risk of lung tuberculosis and 20 lung tuberculosis patients, has been conducted from March–August 2007, at the Dr. Soetomo General Hospital and Karang Tembok Hospital Surabaya. The lung tuberculosis patients included in this study were those with a positive Mycobacterium tuberculosis sputum culture and who had never been treated with anti-tuberculosis drugs. Nurses at risk of lung tuberculosis were those who had been working more than 2 years with negative Mycobacterium tuberculosis sputum culture, chest X-ray and TB-Dot. IL-10 examination (RayBio® Human IL-10 ELISA Kit, RayBiotech, Inc.) was performed using ELISA method. Differences of plasma IL-10 level in both groups were determined by two independent sample t-test. IL-10 cut-off value was determined by Receiver Operator Characteristics Curve and analyzed using Kappa agreement and McNemar test. Results : plasma IL-10 level in lung tuberculosis patients was 14.1 ± 5.3 pg/ml, while in nurses at risk of lung tuberculosis was 6.7 ± 3.3 pg/ml (p<0,001). IL-10 cut-off value was 8.6 pg/ml. Conclusion: plasma IL-10 level in lung tuberculosis patients was significantly higher than in nurses at risk of lung tuberculosis. IL-10 cut-off value was 8.6 pg/ml.

Keyword :

plasma IL-10, lung tuberculosis patients, nurses at risk of lung tuberculosis,


References :

Condos R, Rom WN,(2004) Cytokine Response in Tuberculosis. In: Rom WN, Garay SM, eds. Tuberculosis. 2nd ed. Philadelphia : Lippincott Williams & Wilkins

Daley CL,(2004) Tuberculosis Latency in Human. In: Rom WN, Garay SM, eds. Tuberculosis. 2nd ed. Philadelphia : Lippincott Williams & Wilkins





Archive Article

Cover Media Content

Volume : 45 / No. : 1 / Pub. : 2009-01
  1. Comparison Of Acid-base Balance Change In Hypovolemic Shock With 0.9% Normal Saline Therapy And Ringers Lactate. A Controlled Randomized Clinical Test
  2. The Effectiveness Of Acid Phosphatase And Zinc Tests On The Seminal Fluid Spot Examination As The Primary Identification. A Laboratory Observational Study
  3. The Relationship Between The Width And That Of Dental Arch Of The Upper Jaw In Patients With Down’s Syndrome Which Is Measured By Anthropometric Methods
  4. Immuno-modulatory Effect Of Probiotic And Sublingual Immunotherapy In Asthmatic Children
  5. Difference Of Plasma Interleukin-10 Level In Pulmonary Tuberculosis Patients And Healthy Nurses With Pulmonary Tuberculosis Risk
  6. Isolation Of Male Antifertility Compound In N-butanol Fraction Of Justicia Gendarussa Burm. F. Leaves
  7. Lps Helicobacter Pylori Causative Agent Of The Increase Of Tnf-α, Vcam, E-selectin And Mmp-8 As Indicator Of Endothelial Dysfunction
  8. Hyaluronan, Tnf-α And Estradiol Concentrations In Infertile Women With Endometriosis
  9. Factors Affecting Compliance To Medication In Lung Tuberculosis Patients
  10. Antiseizure And Neurotoxicity Effects Of Ligustrosid Glycoside Isolated From Fraxinus Graffithii Clarke Compared To Phenytoin And Diazepam
  11. Effect Of Andrographis Paniculata Extract On Mammary Carcinoma In Rats Induced By Dmba
  12. Review Article: Ultrasound Elastography: Development Of The Imaging Technique For Tissue Elasticity Assessment
  13. Review Article And Clinical Experience: Thyroid Storm: Quick Diagnosis And Quick Treatment. The Roles Of Formulas G/o–p-39.5 – 120 And Cs-7.1.5

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