UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 39 / No. 3 / Published : 2003-07

Order : 9, and page :188 - 194

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Original Article :

Individualised dose of gentamycin based on clinical pharmacokinetics. a study of prophylactic antibiotic usage in head and neck surgery

Author :

  1. Sunarto Reksoprawiro*1
  2. Ruddy Hartono*2
  3. Siti Sjamsiah*3
  1. Department of Surgery, Airlangga University School of Medicine, Surabaya.
  2. Hospital Pharmacist Training Program, Airlangga University School of Pharmacy, Surabaya
  3. Hospital Pharmacist Training Program, Airlangga University School of Pharmacy, Surabaya

Abstract :

Twenty patients, age of 18-65 years, mean 43.10 years, with normal serum creatine underwent clean contaminated head & neck surgery was divided into two groups. Group I represented those who fit for all dose (80 mg) and group II consisted of those with individualized dose. In both groups gentamycin was administered ½ -1 hour before skin incision. In both groups serum levels of gentamycin were calculated at hour 1 and hour 4 post administration. The gentamycin level of each group were compared, and analyzed by the use of t and F tests. The serum level of gentamycin in 1 hour post administration varied between 2.51 - 6.46 ug/ml (mean 4.366ug/ml) in group I and 3.85 - 5.23 ug/ml (mean 4.558 ug/ml) in group II, variability of gentamycin serum level concentration hour-1 in group I was significantly wider than in group II (F>3.18). The gentamycin serum concentration hour-4 was 1.51 -2.97 ug/ml (mean 2.0l ug/ml) and 1.16-2.39 ug/ml (mean 1.70 ug/ml) in group I and group II respectively, there was no significant difference of variability between the two groups and those gentamycin serum concentrations were still effective as prophylactic antibiotic. The drug side effect monitoring by measuring the serum creatine pre and post operatively for all patients showed that there was no increasing of serum creatine more than 0.5mg/dL. We conclude that with the individualized regimen dose we could ascertain and calculate the effective dose of gentamycin for prophylaxis in surgery, it would give more constant serum concentration especially in hour-1 post administration when the surgery is started, and the serum concentration hour-4 was still effective as prophylactic antibiotic. The individualized regimen dose of entamycin will be safe for the patient because the dose calculation is based on the clinical pharmacokinetic parameters.

Keyword :

individualised dose, gentamycin, pharmacokinetics,


References :

Bauer LA,(2001) Aminoglycoside antibiotics. In Bauer LA (ed.), Applied Clinical Pharmacokinetics New York : McGraw Hills

Chambers HF, Sande MA,(1996) Antimicrobial agent. The Aminoglycoside. In Hardman JG, Limbird LE, Molinoff PB (ed.). Goodman and Gilman's Pharmacological Basis of Therapeutics, 9th ed. New York : McGraw-Hill





Archive Article

Cover Media Content

Volume : 39 / No. : 3 / Pub. : 2003-07
  1. Editorial Vol 39 No 3 2003
  2. Opinion: Establishing The Soetomo As A Teaching Hospital
  3. The Influence Of Electromagnetic Field Extremely Low Frequency (elf) Of 500 Kv High-voltage Transmission Lines To The Spermatogenesis Of Wistar White Rats
  4. Post-adenotonsillectomy Increase Of Immune Response In Children With Obstructive Chronic Adenotonsillitis
  5. Cerebral Malaria Ii. The Role Of Tumor Necrosis Factor In Its Pathogenesis
  6. Review Article And Clinical Experience: Diabetes Mellitus And Endothelial Dysfunction: A Clinical Approach (molecular Basis For Clinical Application)
  7. Difficulties In Health Risk Assessment And Management Resulting From Exposures To Environmental Agents
  8. The Family Background Of Conduct Disorder On Aggressive And Runaway Children
  9. Individualised Dose Of Gentamycin Based On Clinical Pharmacokinetics. A Study Of Prophylactic Antibiotic Usage In Head And Neck Surgery
  10. Binocular Vision Among Children In Second Grade Of Kindergarten School In Surabaya
  11. Education Material Matching In Imci Training Site Dr. Soetomo Referral Hospital

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