UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 47 / No. 4 / Published : 2011-10

Order : 5, and page :219 - 223

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Original Article :

Mechanical ventilation vs nasal cpap duration and the risk of late onset sepsis in premature babies with respiratory distress syndrome

Author :

  1. Hartojo*1
  2. Martono Tri Utomo*2
  1. Division of Neonatology, Department of Child Health, Husada Utama Hospital
  2. Division of Neonatology, Department of Child Health, Faculty of Medicine Airlangga University, Dr. Soetomo Hospital, Surabaya

Abstract :

Mechanical ventilation is frequently required in the management of severely respiratory distress syndrome in premature babies. The risk of late onset sepsis may increase simultaneously with prolonged mechanical ventilation. Objective: To observe the risk of late onset sepsis on the mechanical ventilator and nasal CPAP duration use. Method: retrospective analysis. The data were collected from the medical record of highly risk premature neonates with mechanical ventilation or nasal CPAP in neonatal care unit of Husada Utama Hospital from April 1st 2008 to April 30th 2011 with purposive sampling. Mechanical ventilation and nasal CPAP duration were observed before and after 7 days on placement. Blood culture was performed to establish the risk of late onset sepsis. Chi-square and logistic regression analysis were performed. Result: A total of 44 highly risk premature neonates with Mechanical ventilation or nasal CPAP were enrolled (sepsis group: n= 23 and non sepsis group: n= 21). Baseline demographics were similar between the groups. Prolonged mechanical ventilation > 7 days have significant difference on the risk of late onset sepsis (p=0.035). Prolonged nasal CPAP > 7 days has no significant difference (p=0.667). Burkholderia cepacia and Klebsiella pneumonia mostly appeared in blood culture performance. Conclusions: Prolonged mechanical ventilation may increase the risk of late onset sepsis in premature neonates with respiratory distress syndrome, however nasal CPAP may decrease. 

Keyword :

premature neonates , prolonged mechanical ventilation , late onset sepsis,


References :

Aly H, Badawy M, El-Kholy A, Nabil R, Mohamed A,(2008) Randomized, Controlled Trial on Tracheal Colonization of Ventilated Infants: Can Gravity Prevent Ventilator-Associated Pneumonia? - : Pediatrics

Apisarnthanarak A, Holzmann G, Hamvas A, Olsen MA, Fraser VJ,(2003) Ventilator-associated pneumonia in extremely preterm neonates in a neonatal intensive care unit: characteristics, risk factors, and outcomes - : Pediatrics

Bancalari E, Moral T,(2006) Continuous positive airway pressure: early, late, or stay with synchronized intermittent mandatory ventilation? - : J Perinatol

Bijari BB, Malekiyan A, Niknafs P, Baneshi MR,(2011) Bubble–CPAP vs. Ventilatory–CPAP in Preterm Infants with Respiratory Distress - : Iran J Pediatr

Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG,(2005) Seventy-Five Years of Neonatal Sepsis at Yale: 1928–2003 - : Pediatrics





Archive Article

Cover Media Content

Volume : 47 / No. : 4 / Pub. : 2011-10
  1. Antibiotic Resistance Control Program (arcp) Improving Antibiotic Use In Pediatric Hematology And Oncology Patients At Dr Soetomo Hospital In 2006 And 2008
  2. Sensitivity And Specificity Of Clinical Features Of Influenza Like Illness And Laboratorical Findings For Diagnosed Influenza A (h1n1) In Children
  3. Risk Factors For Birth Asphyxia
  4. Liver Involvement In Children With Dengue Infection
  5. Mechanical Ventilation Vs Nasal Cpap Duration And The Risk Of Late Onset Sepsis In Premature Babies With Respiratory Distress Syndrome
  6. Nucleic Acid Amplification Of The Rpob Region Of Mycobacterium Tuberculosis In Pulmonary Tuberculosis Diagnosis
  7. Effect Of Oral-estrogen Conjugate On B-lymphocyte Proliferation In The Peyer’s Patches Of Adult Female Balb/c Mice Ileum
  8. The Effect Of Emotional Quality Management On Stress, And Optimism In Women With Breast Cancer
  9. Quality And Efficiency Improvement Of Professional Medical Doctor Education In Public Health Field Using Objective Structured Public Health Examination (osphe) Approach At Faculty Of Medicine Airlangga University
  10. Review Article: Role Of Ve-cadherin In Vascular Permeability Regulation
  11. Depth Of Human Hypophysial Fossa Due To Aging Process: A Morphologic Research

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