UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 8, and page :102 - 106

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Original Article :

Pharmacodynamic effects of ligustroside glycoside (a cns active substance) isolated from fraxinus graffithii clarke against chemically induced seizures on mice

Author :

  1. Achmad Basori*1
  1. Department of Pharmacology, Airlangga University School of Medicine, Jl Prof Dr Moestopo 4-7, Surabaya

Abstract :

A study was conducted to prove whether ligustroside (A CNS Active substance) isolated from bark of Fraxinus Graffithii Clarke has antiseizure effects against chemically induced seizure. antiseizure test indicated that ligustroside increased seizure treshold on epileptic animals injected by CD90 metrazol i.p. (ED50 anti Met : 278.54 mg/kg BW), CD90 bicuculline (ED50 anti Bicuc : 424.57 mg/kg BW), and CD90 picrotoxin (ED50 anti Picro : 466.53 mg/kg BW). These experiments also reported that ligustroside decreased metrazol lethality test on animals. The capability of ligustroside to increase seizure threshold against anti metrazol test , anti bicuculline test, and anti picrotoxin test, meant that ligustroside may have antiseizure effects by increasing GABA- facilitated inhibition in CNS through interaction with benzodiazepine receptor of GABA-BZD-BARB/PICRO-CL receptor complexes. It is strongly supposed that clinically ligustroside would be active against absence seizures and myoclonic seizures. Further research will be needed to explore interaction between ligustroside and GABA-BZD-BARB/PICRO-CL receptor complex

Keyword :

ligustroside, chemically induced seizure, antiseizure effect,


References :

Basori, A,(1999) Isolation and pharmacodynamic screening of ligustroside (A CNS active substance) isolated from Fraxinus graffithii Clarke - : Folia Medica Indonesiana

Porter, RJ & Meldrum, BS,(2001) Antiseizure drugs, in BG Katzung (ed), Basic and Clinical Pharmacology, 8th edn NY : Lange Medical Books





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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