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Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 9, and page :269 - 273

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Original Article :

Potency of lactobacillus reuteri on reduced inflammation in septic encephalopathy

Author :

1. OS Hartanto*¹
2. Diding HP*²

1. Medical Faculty of Sebelas Maret University Surakarta-Indonesia
2. Medical Faculty of Sebelas Maret University Surakarta-Indones

Abstract :

Sepsis is the leading cause of death in critically ill patients. Septic encephalopathy is a severe brain dysfunction caused by systemic inflammation in the absence of direct brain infection. Intestinal apoptosis plays a central role in the pathophysiology of sepsis and is associated with a poor outcome in sepsis. In experimental animals model of sepsis, improve intestinal inflammation lowers survival due to sepsis. Lactobacillus reuteri is recently used as immunonutrition in critically ill patients is still disputed. This study was aimed to evaluate the effect of L. reuteri on intestinal inflammation grade in mice model of sepsis. Male Balb/C mice weighing 15-23 g were used in the study. Mice models of sepsis were induced by an intraperitoneally (i.p). injection 4 mg/mice of cecal inoculum each day for 7 days. The mice were divided into three groups: control (n=6), sepsis (n=6) and sepsis plus L. reuteri (n=6). Mice were sacrificed 24 hours after the final cecal inoculation to determine intestinal inflammation grade. We used L. reuteri as probiotic. Mann-Whitney test for intestinal inflammation grade at p < 0.05 was used to determine significant differences of each group. Control group mice showed intestinal inflammation of 94,4% on grade 0; while sepsis mice group (cecal inoculum exposed) demonstrated higher grade of intestinal inflammation of 55,6% on grade 3; and sepsis plus L. reuteri mice group showed higher than control group but lower compared to sepsis without L. reuteri group, namely 50% on grade 0. It can be concluded that L. reuteri can reduced inflammation in mice model of sepsis including septic encephalopathy.

Keyword :

sepsis, probiotic , cecal inoculum,

References :

O'Connor, JJ ,(2007) Crash Course Pathology, 2nd edn St Louis : CV Mosby Co.

Brown, AC and Valiere, A,(2004) Probiotics and medical nutrition therapy - : Nutr Clin Care

Chopra, M and Sharma, AC,(2007) Distinct cardiodynamic and molecular characteristics during early and late stages of sepsis-induced myocardial dysfunction - : Life Sci

Archive Article

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Content

Volume : 44 / No. : 4 / Pub. : 2008-10

Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004 The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data Encephalopathy And Neuroendocrine Disorder In Septic Shock Osteoarthritic Pain Treatment With Electroacupuncture Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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