UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 4 / Published : 2006-10

Order : 11, and page :271 - 276

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Original Article :

Review article and clinical experience: thyroid storm: a life-threatening thyrotoxicosis therapeutic clinical experiences with formula ts 41668-24-6

Author :

  1. Askandar Tjokroprawiro*1
  1. Airlangga University School of Medicine Diabetes and Nutrition Center, Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

Thyroid Crisis (TC) or Thyroid Storm (TS) is an acute, life-threatening, thyroid hormones-induced hypermetabolic stateinvolving multiple systems in patients with thyrotoxicosis or those who are previously unrecognized thyrotoxicosis. TheBurch-Wartofsky-Point Score (BWPS) has been widely used in Surabaya as a device of diagnostic criteria for TS.Formula TS 41668-24-6 has been used as specific practical guideline in the treatment of TS and its therapeutic clinicaloutcomes. The description of this Formula can be followed below. "4” means: 400 mg loading dose of PTU, withmaintenance dose: 100-200 mg PTU every 4 hours. PTU is given to inhibit TH synthesis and to inhibit the conversion ofT4 10 T3. Alternatively, methimazole: 40 mg as a loading dose can be given, with maintenance dose 10 mg every 4hours. "1" means: PTU should be administered at least 1 hour before giving iodine to establish blockade of hormonesynthesis. The first “6" means: 6 drops of Lugol's solution or SSKI every 6 hours to inhibit TH release from thyroidgland and should be evaluated after 6 days. The second "6" means: administration 10-40mg propanolol every 6 hoursto decrease heart rate, myocardial contractility, blood pressure, and myocardial oxygen demand. Reevaluation ofpropanolol administration should be done after 6 days. "8" means: 100-200 mg IV hydrocortisone hemisuccinate every8 hours to block the conversion of T4 to T3. Stress dose are required to replace accelerated production anddegradation of cortisol induced by TH. "24" means: with adequate thyroid-suppressive therapy and sympatheticblockade, clinical improvement should occur within 24 hours. The last "6" means: adequate therapy should resolve theTS within 6 days.

Keyword :

Thyroid Crisis (TC), Thyroid Storm (TS), thyrotoxicosis, The Burch-Wartofsky-Point Score (BWPS), Formula TS 41668-24-6,


References :

Ghobrial, MW & Ruby, EB,(2002) Come and thyroid storm in apathetic thyrotoxicosis - : South Med J

Burch, HB & Wartofsky, L,(1993) Life-threatening thyrotoxicosis: Thyroid Storm - : Endocrinol Metab Clin North Amer





Archive Article

Cover Media Content

Volume : 42 / No. : 4 / Pub. : 2006-10
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  2. Effect Of Low Intensity Exercise On Glucose Intolerance In The Depo Medroxyprogesterone Acetate (dmpa) Injected Rat
  3. The Role Of Care, Support And Treatment To Biological Parameters And Clinical Changes Of Plwha In Idicu
  4. The Effect Of Melanin Concentration On Collagen Accumulation In Keloid
  5. The Effects Of Exercise Response On Creatine Kinase In White Wistar Rats
  6. New Paradigm In Oral Focal Infection: Periodontal Disease As An Etiology Of Migraine-anxiety Related Dizziness (mard)
  7. Clinical Manifestation Of Systemic Lupus Erythematosus Mimicking Tuberculosis In A 4 Year-old Child
  8. Case Report: Staphylococcal Scalded Skin Syndrome In A Neonate
  9. Review Article: Hand Deformities In Rheumatoid Arthritis
  10. Review Article: Screening And Management Of Retinopathy Of Prematurity
  11. Review Article And Clinical Experience: Thyroid Storm: A Life-threatening Thyrotoxicosis Therapeutic Clinical Experiences With Formula Ts 41668-24-6

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