UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 8, and page :264 - 268

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Original Article :

The pharmacokenetics of levofloxacin in healthy rabbit treated with antacid

Author :

  1. Aniek Setiya Budiatin*1
  2. Weni Kristanti *2
  3. Suharjono*3
  1. Departement of Clinical Pharmacy, Airlangga University School of Pharmacy
  2. Departement of Clinical Pharmacy, Airlangga University School of Pharmacy
  3. Departement of Clinical Pharmacy, Airlangga University School of Pharmacy

Abstract :

The effect of antacid (Antasida DOEN) 14 ml/ kg BW which containing polyvalent cation Mg (OH)2 and Al(OH) 3 on the absorption of levofloxacin were examined in healthy rabbit. Twelve subjects were administered 23 mg/ml kg BW levofloxacin alone. On day 8 the six subjects were administered antacid and levofloxacin concomitant and the other were administered antacid two hours after levofloxacin. There were statistically significant different in pharmacokinetic parameter produced by administration with antacid concomitant but the other one were not significant different. There were Cmax and AUC decrease (p<0.05) but tmax increase was not significant different (p>0.05) for administration concomitant and but the other one were C max, AUC and tmax smaller than control but not significant different (p>0.05). The different had apparent effect on the plasma concentrations of levofloxacin and was determined with spectrofluorometric.Antacid may reduce the absorption of levofloxacin, the extent of this interaction appears to increase as time between administration of two drugs decreases.

Keyword :

levofloxacin, Mg (OH)2 and Al(OH) 3 , antacid , spetrofluorometric,


References :

Brighty, Katherine, E. Gootz, Thomas D,(2000) Chemistry and mechanism of action of the quinolone antibacterials, in VT Andriole (ed) The Quinolones London : Academic Press

Evans, G,(2004) A Handbook of Bioanalysis and Drug Metabolism USA : CRC Press

Shargel, L, Wu Pong, Susana, Yu, ABC,(2005) Applied Biopharmaceutics and Pharmacokinetics, 5th edn Boston : The McGraw-Hill Companies, Inc.





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection
  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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