UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 3 / Published : 2006-07

Order : 7, and page :172 - 175

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Original Article :

The pharmacokinetics of lamivudine in healthy rabbit treated with cimetidine

Author :

  1. Aniek Setiya Budiatin*1
  2. Toetik Aryani*2
  1. Department of Biomedical Science, Airlangga University School of Pharmacy, Surabaya
  2. Department of Biomedical Science, Airlangga University School of Pharmacy, Surabaya

Abstract :

The effects of cimetidine on the plasma concentration of Lamivudine (3TC) were examined in rabbits. Three subjects were given 14 mg/kg BW lamivudine alone. On day 8, the three subjects were given 78 mg/kg BW cimetidine one hour before a dose of lamivudine. There were statistically significant differences in the pharmacokinetic parameter produced by administration with cimetidine. There were C max and AUC 0-120 but t max was no difference. The different had apparent effect on the plasma concentrations of lamivudine and was determined with HPLC

Keyword :

lamivudine, cimetidine, HPLC,


References :

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RMW 1998,(1998) Quantitative determination of (-)-2’-deoxy-3’-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chroma-tography with ultraviolet detection no info : J Chrom B

KHP Moore,(1999) Lamivudine/zidovudin as a Combined Formulation Tablet: Bioequivalence Compared with Lamivudine and Zidovudin Administered Concurrently and the Effect of Food on Absorption no info : J Clin Pharmacol

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Archive Article

Cover Media Content

Volume : 42 / No. : 3 / Pub. : 2006-07
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  2. Pattern Of Transforming Growth Factor-ß1 (tgf-ß1) Level In Bph And Non-bph Patients
  3. Changes In The Level Of Acth, Cortisol And Lymphocyte T Count After Establishing Diagnosis Of Hiv And Aids
  4. The Effect Of Aerobic Exercise On The Erythrocyte Osmotic Fragility Of The Wistar White Rats
  5. The Equation Analysis Of Linear Pharmacokinetics Models By Akaike's Information Criterion (aic) Of Diminazene Aceturate In Blood Plasma
  6. Comparison Between 0.1% Diclofenac Natrium And 0.1% Dexamethasone Eyedrops In Reducing Cataract Postoperative Inflammation
  7. The Pharmacokinetics Of Lamivudine In Healthy Rabbit Treated With Cimetidine
  8. Validity And Reliability Of Radar Questionnaire For Patients With Rheumatoid Arthritis
  9. Height Measurement Based On Sternal Bone Length In Adults
  10. Antimicrobial Resistance And Antibiotic Use In Low-income And Developing Countries
  11. Urethral Stricture In Female
  12. Review Article And Clinical Experience: Recent Advances In Diabetes Mellitus: 2002-2005. Selected Clinical Aspects, Clinical Experiences, And Possible Applications

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