UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 3 / No. 2 / Published : 2014-12

Order : 3, and page :75 - 81

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Original Article :

Chemopreventive effect of gynura procumbens (lour) merr, on the histopathology of mammary gland in the rats that was induced 12-dimethylbenz(α)antrasen

Author :

  1. Iwan Syahrial Hamid*1
  1. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this research is to determine the effect of etanolic extract of Gynura procumbens leaves in the prevention of breast cancer by inhibit changes epithelial cells of mammary gland as histopathology changes of breast cancer. The Sprague dawley rats were divided into 4 groups of treatments. Etanolic extract of Gynura procumbens was given everyday in 2 doses (300 and 750 mg/kg bw) for 7 weeks. DMBA, which was used to induct breast cancer, was given twice a week start at 3rd week until 7th weeks. Tumor progression was inspected until the 12th  weeks after the last initiation of DMBA. The changes of histopatology was quantified by HE method. Result of this study demonstrated that etanolic extract of Gynura procumbens leaves with 300 and 750 mg/kg bw could significantly inhibit carcinogenesis in mammary histopathology. Histopathological describe showed to inhibition hyperplasia to epithelial cells of mammary gland. The comparation between 300 and 750 mg/kg bw show that 300 mg/kg bw  more effectively decreasing hyperplasia to epithelial cells of mammary gland  and inhibit carcinogenesis in mammary histopathology. It can be concluded that ethanolic extract of Gynura procumbens leaves with 300 mg/kg bw could give chemopreventive effect on mammary carcinogenesis.    

Keyword :

Hyperplasia, Gynura procumbens, Histopathology , DMBA,


References :

Budhy T. ,(2004) Mekanisme kejadian karsinoma sel skuamosa rongga mulut yang terinfeksi Epstein Barr Virus (EBV) berdasarkan ekspresi p53, c-myc dan bcl-2. [Thesis]. Surabaya : Fakultas Kedokteran Gigi. Universitas Airlangga.

Oliff A, Gibbs JB., Mc Cormick, F. ,(1996) New molecular targets for cancer therapy. Amerika : Scienti Am 275 (3): 110-115.

Suganda, A.G., Iwang, S. dan Ganthina. ,(1988) Skrining Fitokimia dan Asam Fenolat dalam daun dewa, Jakarta. : Simposium Penelitian Tumbuhan Obat III, UI,





Archive Article

Cover Media Content

Volume : 3 / No. : 2 / Pub. : 2014-12
  1. The Study Of Cross Reactivity Between H5 Clade 2.3.2 Serum And H5 Clade 2.1.3 Virus By Using Serum Neutralization Test
  2. The Inhibition Effect Of Pluchea Indica Less. Leaf Extract To Pasteurella Multocida (in-vitro) By Diffusion Disk Method
  3. Chemopreventive Effect Of Gynura Procumbens (lour) Merr, On The Histopathology Of Mammary Gland In The Rats That Was Induced 12-dimethylbenz(α)antrasen
  4. The Effect Of Meniran (phyllantus Niruri, Linn.) In Increasing The Number Of Total Leukocytes And Leukocyte Counts Of Eimeria Tenella Infected Broiler
  5. Antiviral Effectivity Extract Of Pomegranate Rind (punica Granatum L. ) Against Newcastle Disease Virus In Embryonated Chicken Egg
  6. Profile Of Bone Calcium Levels In The Rat (rattus Norvegicus) After The Repositioning Fractures Of The Femur With Tikel Balung (cissus Quadrangularis) Extract Theraphy
  7. Teat Dipping Effectiveness Using Red Betel (piper Crocatum) Leaf Boiling And Iodine On Growth Of Bacteria
  8. Influence Of Infusa Mangosteen Peel (gracinia Mangostana L) For Blood Glucose Levels Of Hyperglycemic Rats
  9. Potential Of Crude Chlorella As Antibacterial Againts Salmonella Pullorum In Vitro
  10. The Potential Of Red Roses Extract (rosa Damascena Mill) As An Antiseptic Stomatitis In Snakes (python Reticulatus) On The Total Number Leukocyte And Defferential Counting Of Leukocytes

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