UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 4 / No. 2 / Published : 2015-12

Order : 12, and page :149 - 154

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Original Article :

Rosella (hibiscus sabdariffa linn) extract as hepatoprotector on lead poisoning

Author :

  1. Rochmah Kurnijasanti*1
  2. Tutik Juniastuti1*2
  3. Sri Agus Sudjarwo*3
  1. Dosen Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This study aims to prove the antioxidant effects of roselle in preventing liver cell damage due to increased free radical formation in heavy metal poisoning of lead (Pb acetate). The research used 30 mice that were divided into 5 groups as follows: Negative control: the mice were given only the solvent of lead acetate and solvent of roselle extracts, positive control: the mice were given the lead dose of 20 mg / kg body weight and solvent of roselle extracts, Treatment 1, 2 and 3: the mice were given the roselle extracts each with a dose of 200 mg / kg body wight, 400 mg / kg body weight and 800 mg / kg body weight, and treatment of the mice was also given a dose of 20 mg / kg body weight of lead acetate. Roselle extracts given orally in advance for 7 days, then on the eighth day, the mice were also given a lead orally, one hour after the administration of the roselle extracts. The process of giving roselle extract and lead was conducted over 21 days. On 29th day, blood samples were taken to examine SGOT and SGPT level on the mice. The result showed that roselle extract inhibits the increase of SGOT and SGPT level in mice that were exposed to lead acetate.  

Keyword :

Rosella extracts, Hepatoprotector, Lead acetate, SGOT, SGPT,


References :

Patrick, L. ,(2006) The role of free radical demage and the use of anto\ioxidants in the pathology and treatment of lead toxicity. 11(2): 114-127. : Altern Med Rev

González, C. S, Balderas, F.T. V, Regules, A. E. O and Beltrán, J.Á. ,(2011) Antioxidant properties and color of Hibiscus sabdariffa ex-tracts. 11-23 : BioMed Central Ltd unless otherwise stated. Part of Spring¬er Science+Business Media.





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2015-12
  1. The Effect Of Giving Vitamin C On Endosulfan Induced In Histopathologic Liver Of Mice (mus Musculus)
  2. Influence Of Hibiscus Sabdariffa L. Calyx On Alveolar Histopathological Feature Of Cigarette Smoke Exposed Mice
  3. The Effect Of L-arginine Orally On The The Histologycal Of Seminiferous Tubules Of Rabbit (oryctolagus Cuniculus) Testicular
  4. Infusum Cincau Green Leaves As The Use Inflammatory Gastric On White Rat (rattus Norvegicus ) Induced Use Caffeine With Inspection Histopathology
  5. The Influence Of Sambiloto Leaf (andrographis Paniculata) Extract As An Imunostimulator Against The Proliferation Of Lymphocyte
  6. Effects Of Plant Wood Yellow Leaf Extract (arcangelisia Flava Merr) As To Prevent Hepatic Dysfunction Examination Levels Of Bilirubin, Sgot Sgpt And Serum Blood On White Rat (rattus Norvegicus)
  7. Activitiy Test Of Snail Mucus (achatina Fulica) On The Healing Level Of Incision Wound Grossly And Microscopically In Batik Python Snake (python Reticulatus)
  8. Prevalence And Degree Of Gastrointestinal Helminth Infections In Cervus Timorensis (blainville 1822) (timor Deer) And Axis-axis (exrl 1788) (axis Deer) In The Pendopo Tulungagung
  9. Antibacterial Activity Of Phyllanthus Niruri L Extract As Substitute Alternative Flumequin Antibiotic To E. Coli On Broiler
  10. The Effects Of Propolis On Histopatological Liver In Male Mice (mus Musculus)
  11. Antibacterial Potential Of Euphorbia Hirta L. Extracts Toward Staphylococcus Aureus Growth Through In Vitro Method
  12. Rosella (hibiscus Sabdariffa Linn) Extract As Hepatoprotector On Lead Poisoning

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