UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 1 / No. 1 / Published : 2014-01

Order : 7, and page :31 - 33

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Original Article :

Studi kelarutan dan disolusi kompleks inklusi ketoprofen-hidroksipropil -siklodekstrin (dibuat dengan metode kopresipitasi)

Author :

  1. Bambang Widjaja*1
  2. Achmad Radjaram*2
  3. Herwinda Widi Utami*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Mahasiswa Fakultas Farmasi

Abstract :

The aim of this research was to enhance the solubility and dissolution rate of ketoprofen through inclusion complexes by hydroxypropyl β-cyclodextrin. Inclusion complexes were prepared by coprecipitation method with 1:1 molar ratio. Solubility and dissolution test were carried out to evaluate the formation of inclusion complexes. Ketoprofen-hydroxypropyl β-cyclodextrin inclusion complexes showed higher solubility, dissolution rate and dissolution efficiency than its physical mixture and pure drug. Inclusion complexes by hydroxypropyl β-cyclodextrin increased the solubility and dissolution rate of ketoprofen.

Keyword :

hydroxypropyl β-cyclodextrin, solubility, ketoprofen, inclusion complexes, dissolution rate,


References :

Shargel L, Yu ABC,(2005) Biofarmasetika dan Farmakokinetika Terapan Surabaya : Airlangga University Press

Bekers O, Uijtendaal EV, Beijnen DA, Bult A, Underberg WJM,(1991) Cyclodextrin in the Pharmaceutical Field - : Drug Dev. Ind. Pharm

Challa R, Ahuja A, Ali J, Khar RK,(2005) Cyclodextrins in Drug Delivery : An Updated Review - : Pharmaceutical Science Technology

Hladon T, Pawlaczyk J, Szafran B,(1999) Stability of Mefenamic Acid in The Inclusion Complex with -cyclodextrin in The Solid Phase - : Journal of Inclusion Phenomena and Macrocyclic Chemistry

Loftsson T, Duchêne D,(2007) Cyclodextrins and Their Pharmaceutical Applications - : International Journal of Pharmaceutics





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
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  4. Aktivitas Antiviral Batang Eucalyptus Globulus Terhadap Virus Hepatitis C Jfh1a
  5. Sintesis Khalkon Dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt Dengan Iradiasi Gelombang Mikro
  6. Penentuan Dosis Asam P-metoksisinamat (apms) Sebagai Antiinflamasi Topikal Dan Studi Penetrasi Apms Melalui Kulit Tikus Dengan Dan Tanpa Stratum Korneum
  7. Studi Kelarutan Dan Disolusi Kompleks Inklusi Ketoprofen-hidroksipropil -siklodekstrin (dibuat Dengan Metode Kopresipitasi)

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