UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 7 / No. 5 / Published : 2011-06

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Original Article :

The role of ascorbic acid on endothelial cell damage in phacoemulsification

Author :

  1. Nika Bellarinatasari*1
  2. Wasisdi Gunawan*2
  3. Tri Wahyu Widayanti*3
  4. Hartono*4
  1. Department of Ophthalmology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito General Hospital, Yogyakarta

Abstract :

The objective of this study is to compare the corneal endothelial cell loss due to phacoemulsification surgery in ascorbic acidgroup and placebo group. This was a clinical study with double blinds randomized controlled trial. There were 66 subjects enrolled, divided into 2 groups: ascorbic acid group that was given 2 g orally with divided doses 500 mg four times at night, morning, afternoon and 2 hours before surgery (n = 32) and placebo group (n = 34). Endothelial cell counts was performed before and 7 days after phacoemulsification surgery. Administration of 2g ascorbic acid in divided doses of 500 mg given 4 times before phacoemulsification surgery caused less corneal endothelial cell loss 229,27 ± 191,58 cells/mm2(9.10% ± 6.88%) compared with the administration of placebo which had endothelial cell loss 364,64 ± 255,25 cells/mm2 (14.85% ± 10.54%). There was statistically significantly different in endothelial cell loss between the two groups (p < 0.05), but no clinically significantly different. The baseline characteristic between the both groups was similar. Administration of 2 g ascorbic acid in divided doses of 500 mg given 4 times before phacoemulsification surgery can reduce the corneal endothelial cell loss.

Keyword :

phacoemulsification, ascorbic acid, endothelial cell loss,


References :

Istiantoro S, Johan AH,(2004) Transisi Menuju Fakoemulsifikasi Jakarta : Granit

Gardner JM, Aust SD,(2009) Quantification of hydroxyl radical produced during phacoemulsification Amerika : J Cataract Refract Surg

Takahashi, H,(2005) Free radical development in phacoemulsification cataract surgery - : J Nippon Med Sch

Nemet AY, Assia EI, Meyerstein D, Meyerstein N, Gedanken A, Topaz M,(2007) Protective effect of free-radical scavengers on corneal endothelial damage in phacoemulsification - : J Cataract Refract Surg

Rose RC, Richer ST, Bode AM,(1999) Ocular oxidants and antioxidant protection - : Society for Experimental Biology and Medicine





Archive Article

Cover Media Content

Volume : 7 / No. : 5 / Pub. : 2011-06
  1. Limbal Dermoid And Pre-auricular Tag In A 12 Years Old Girl
  2. Vitrectomy And Silicone Oil Tamponade In The Management Of Retinal Detachment In Marfan Syndrome Patient
  3. Crouzon Syndrome
  4. Histopathologic Profile Grading Of Haematoxylene Eosin On Retinoblastoma Stadium
  5. Decrease Of Corneal Sensitivity In Patients With Diabetes Mellitus Type Ii
  6. Glaucoma Caused Blindness With Its Characteristic In Cipto Mangunkusumo Hospital
  7. Visual Field Abnormality And Quality Of Life Of Patient With Primary Open Angle Glaucoma
  8. The Role Of Ascorbic Acid On Endothelial Cell Damage In Phacoemulsification
  9. The Risk Factors Of Human Papilloma Virus 18 On The Recurrences Of Pterygium
  10. Crouzon Syndrome

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