Majalah Kedokteran Respirasi
ISSN 0216-5899
Vol. 4 / No. 2 / Published : 2013-05
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Original Article :
Tatalaksana hiperurisemia akibat penggunaan pyrazinamide pada penderita tuberkulosis
Author :
- Febe Adriana*1
- Winariani Koesoemoprodjo*2
- PPDS I IP Dalam FK Unair/RSU Dr. Soetomo Surabaya.
- Staf Bag/SMF IP Paru FK Unair/RSU Dr. Soetomo Surabaya
Abstract :
ABSTRACT : Hyperurisemia is a condition when uric acid level in blood above normal value. It is caused by increasing of uric acid production or decreasing of uric acid excretion, 90% of hyperurisemia caused by decreasing of uric acid excretion. Pyrazinamide is one of first line drugs for anti-tuberculosis, more than one-third people worldwide has tuberculosis. Two million people died because of tuberculosis every year. A cohort retrospective study revealed, one of 4 major side effects in tuberculosis theraphy is hyperurisemia that is induced by pyrazinamide. Mechanism, diagnosis and management of pyrazinamide induced hyperurisemia in tuberculosis patients are important to be known.
Keyword :
pyrazinamide, hiperurisemia, drug induced hiperurisemia,
References :
Fourie PB, Mitchison DA,(2010) The near future: Improving the activity of rifamycins and pyrazinamide Unknown : Tuberculosis 90:177-181
Zhang Y,(2003) Mode of Action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetic by pyrazinoic acid Unknown : J Antimicrob Chemother
Archive Article
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 Volume : 4 / No. : 2 / Pub. : 2013-05 |
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