UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 5, and page :159 - 166

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Original Article :

Activity of alkaloid of jarong leaves (achyranthes aspera linn ) on the death of cancer cells in the breasts of mice (mus musculus)

Author :

  1. Rahma Putri Anggraini*1
  2. Dewa Ketut Meles*2
  3. Eka Pramyrtha Hestianah*3
  4. Wurlina*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this study was to describe activity of alkaloid of jarong leaves(Achyranthes aspera Linn ) on the death of cancer cells in the breasts cancer of mice (Musmusculus). Twenty four mice were divided into six treatment groups which each groupconsists of four mice, K- as control were induced CMC Na 0,5%, meanwhile K+, P0, P1,P2, and P3 were induced with Benzo[a]pyrene, and then given alkaloid of jarong leaves(Achyranthes aspera Linn ) and metotreksat for positive control. Sacrified and staining atweeks as seventeen and eighteen. The data of apoptosis and necrosis breast cancer cellswas analyzed using One way Anova test and continued by Honestly Significant Differencetest. The result of this study showed there were significant (p˂0,05), but between positivecontrol and P1,P2,P3 given same effect in apoptosis and necrosis incident of breast cancerdeath. The present study shows that alkaloid of jarong leaves (Achyranthes aspera Linn )has a therapeutic dose almost similar to metotreksat.

Keyword :

Alkaloid, Achyranthes aspera Linn, breast cancer, breast cancer, .,


References :

Djoerban, Z.,(2003) Kanker Payudara:Yang Penting dan Perlu Diketahui 4(2) : Medicinal:Jurnal Kedokteran

Meles, D.K.,(2007) Alkaloid Achyranthes aspera linn Menyebabkan Nekrosis dan Apoptosis Sel Mieloma 23(1) : Media Kedokteran Hewan

Yalon, M., S.Gal., Y. Segev, and K.I. Skorecki,(2004) Sister Chromatid Separation at Human Telomeric Region 67(6):1113- 1118 : J.Cell Sci.





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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