Veterinaria Medika
ISSN 1979-1305
Vol. 10 / No. 1 / Published : 2017-02
Order : 12, and page :87 - 92
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Original Article :
The effects of propolis on histological liver in male mice (mus musculus)
Author :
- Bagus Pandu Satrio Utomo*1
- Eka Pramyrtha Hestianah*2
- Julien Soepraptini*3
- Mahasiswa Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
Abstract :
The aim of this research was to find out the effects of propolis on histological liverin male mice (mus musculus). This research used 25 male mice which are 12 weeks oldwhich has 25-35 g of body weight. They were divided randomly into five groups. (P0) asa control was given tween 80 0.5 ml/KgBW/day, and other group were given propolis for(P1) 0,4 mg /KgBW/day, (P2) 0,8 mg /KgBW/day, (P3) 1,6 mg / KgBW/day, and (P4) 3,2mg / KgBW/day. After two weeks treatment, the mice eutiniced by cervical dislocationand then took the liver for the histological preparations. The histological staining used H.E.The data were analyzed by Kruskall-Wallis method based on Completely RandomizedDesign, and further analyzed by Z test. The result from statistical analysis showed thattreatment with propolis effect on histological liver in male mice did not give a bad effecton the body, so the propolis is safe for consumption.
Keyword :
Propolis, liver, mice, histological,
References :
Brunt, E.M., C.G. Janney, A.M. Di Bisceglie, B.A. Neuschwander-Tetri and B.R. Bacon. ,(1999) Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging the Histological Lesions. 94: 2467- 2474. : American Journal of Gastroenterology.
Junqueira LC, Carneiro J. ,(2007) Histologi dasar. Edisi 10. : EGC. Jakarta.
Kay, E. R. M. ,(1965) The Effects of Tween 80 on the in Vitro Metabolism of Cells of the Ehrlich- LettréAscites Carcinoma. 1 : Cancer Res.
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