UNIVERSITAS AIRLANGGA



Detail Article

Media Kedokteran Hewan

ISSN 2015-8930

Vol. 30 / No. 1 / Published : 2014-01

Order : 7, and page :61 - 66

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Original Article :

Grant of ethanol extract of seeds papaya (carica papaya) in female rats (rattus novergicus) as an alternative antifertility material to fertilization number

Author :

  1. Yenny Puspitasari*1
  2. Byba Melda Suhita*2
  3. Pudji Srianto*3
  4. Widjiati*4
  1. Fakultas Keperawatan STIKes Surya Mitra Husada
  2. Fakultas Keperawatan STIKes Surya Mitra Husada
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

Abstrak Indonesia merupakan negara berkembang dengan masalah kepadatan penduduk peringkat empat dunia. Usaha yang dilakukan untuk menekan pertumbuhan penduduk melalui Keluarga Berencana. Sebagai upaya mensukseskan Keluarga Berencana dengan mengembangkan bahan baku antifertilitas bahan alam dari pepaya. Tujuan penelitian ini mempelajari efek ekstrak etanol biji pepaya terhadap antifertilitas pada mencit betina. Manfaat penelitian ini memberi informasi tentang manfaat ekstrak etanol biji pepaya sebagai antifertilitas pada hewan dan memberi alternatif ekstrak etanol biji pepaya sebagai obat kontrasepsi. Penelitian ini menggunakan post-test only control group. Sampel diambil secara acak. Variabel bebas adalah ekstrak etanol biji pepaya dalam berbagai dosis. Variabel dependen adalah angka fertilisasi. Analisis data untuk menentukan angka fertilisasi dilakukan dengan uji ANAVA satu arah. Pemberian ekstrak etanol dari biji pepaya dalam dosis 100 mg/kg, 200 mg/kg, 300mg/kg menunjukkan penurunan angka fertilisasi dan tidak ada perbedaan angka fertilisasi antar perlakuan setelah memperoleh ekstrak etanol biji pepaya. Hal ini ditunjukkan dari nilai p = 0,000 α = 0,0. Pemberian ekstrak etanol biji pepaya adalah menyebabkan infertilitas, menurunkan angka fertilisasi pada tikus betina.   AbstractIndonesia is a developing country with population density problem occupies the fourth rank of the world. One effort made to suppress the population growth is through family planning. One of the efforts to succeed family planning is the development of rawYenny Puspitasari, dkk. Pemberian Ekstrak Etanol Biji Pepaya ....62materials from papaya for antifertility natural ingredients. The purpose of this research was to study the effects of ethanol extract of papaya seeds on antifertility in female rats. The benefits of this research was to provide information about the use of ethanol extract of papaya seeds as antifertility in animals and make ethanol extract of papaya seeds as an alternative contraceptive drug. This study used post-test only control group design. Samples were taken in random. The independent variable was ethanol extract of papaya seeds in various doses. The dependent variables were folliculogenetic examination, increase infertility, decresed quality egg and fertilization number. Data analysis to determine the different mean number of follicles, increase infertility, decresed quality egg and fertilization number weer performed with one-way ANAVA test. Ethanol extract of papaya seeds in dose of 100 mg/kg, 200 mg/kg, 300 mg/kg decrease fertilization number and no difference in fertilization number. It is shown from the value of p = 0.000 α = 0.05. Ethanol extract of papaya seeds is infertility, decrease fertilization number, causing infertility in female rats.

Keyword :

ethanol extract of papaya seeds, , folliculogenesis, infertility, eggs quality, , number fertilization,


References :

Astirin OP dan Muthmainah.,(2002) Struktur Histologis Ovarium Tikus (Rattus novergicus) Gravid Setelah Pemberian Ekstrak Momordica Charantia L. J. Pharmacon. Jakarta. 26-30 - : -

Burrow ME, Bone SM, Coelin BM, Meinik LI, Duana BN, Canter SW, Wiese TE, Cleveland TE and Mc. Lachla,(2001) Phytochemical Gliceolins Isolated from Soy Medicine Antihormonal Effect Through Esterogen Receptor Alpha and Beta. J. Clin. Endocrinol. Metab. Apr. 86 (4) : 1750-1758. - : -

Francis G, Kerem Z, Makkar HPS and Becker K.,(2002) The Biological action of saponins in animal system: review. British Journal Of Nutrition 88:587-605. - : -

Garor R, Abir R, Erman A, Felz C, Nitke and Fish B.,(2009) Effect of Basic Fibroblast Grotwh Factor on In Vitro Development of Human Ovarian Primordial Follicles. Fertility and Sterility 91(5): 1967-1975. - : -

Gomez Y, Velazques PN, Pelalta ID, Mendez MC, Vilchia F, Juarez MAO and Pedenernera E.,(2001) MAO and Pedenernera E. 2001. Follicle Stimulatin



Archive Article

Cover Media Content

Volume : 30 / No. : 1 / Pub. : 2014-01
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  2. Peningkatan Kualitas Semen Beku Kambing Pe Melalui Suplementasi Antioksidan α–tocoferol Dalam Pengencer Semen Untuk Inseminasi Buatan
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  4. Characteristic Of Carcas, Meat Tenderness And Marbling Of Beef Cattle At Manokwari
  5. Concentration Determination Of Growth Factor Insuline Like Growth Factor-1 (igf-1) Produced By Liver And Cumulus Cells Monolayer Culture
  6. Morphometry Of The Kidney And Abdominal Aorta Of Indonesian Domestic Cat Through Two Dimensional Ultrasonography Diagnostic Approach
  7. Grant Of Ethanol Extract Of Seeds Papaya (carica Papaya) In Female Rats (rattus Novergicus) As An Alternative Antifertility Material To Fertilization Number
  8. The Potency Of Potassium Chloride And Sodium Bicarbonate Suplementation As Thermotolerance Agent On Liver Of Chronic Heat-stressed Broiler

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