UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 2 / No. 1 / Published : 2013-07

Order : 2, and page :13 - 17

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Original Article :

Pengaruh formulasi terhadap efekifitas antimikroba ekstrak etanol 70% daun cassia alata linn pada candida albicans

Author :

  1. Tristiana Erawati*1
  2. Widyasworo Ratri*2
  3. Hilmah*3
  4. Noorma Rosita*4
  1. Dosen Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Mahasiswa Fakultas Farmasi
  4. Dosen Fakultas Farmasi

Abstract :

The ethanolic extract of Cassia alata Linn leaves has been known having great activity against genre fungus including Candida albicans; it’s one of the funguses that mostly cause stomatitis aphtuosa recurrent. Mucoadhesive gel mostly use as bases of stomatitis aphtuosa recurrent medicine. The aims of these study is to determine the effect of mucoadhesive gel (1% Carbomer ETD 2020 gel base and in 5% CMC Na gel base) on Cassia Alata Linn leaves ethanolic extract (3.55 – 25% w/w in the gels) against Candida albicans, compared with Nystatin (3.33% w/w) in the same bases. The physical characteristics of all formulas were investigated included the organoleptic character, pH, and mucoadhesiveness. In vitro inhibition effects on Candida albicans growth were determined by diffusion method. The data were analysed statistically by ANOVA-one way. The result showed that ethanolic extract Cassia alata Linn leaves decreased both pH value and mucoadhesiveness of gel bases. The ethanolic extract Cassia alata Linn leaves in concentrations 80, 120 and 160 mg/mL (8, 12, and 16%) are effective as antimicrobial against candida albicans. But if it formulated in 1% Carbomer ETD 2020 or 5% CMC Na gel bases have lost its efficacy against Candida albicans.

Keyword :

Cassia Alata Linn, Stomatitis Aphtuosa Recurrent, Antimicrobial Activity , Carbomer ETD 2020, CMC Na,


References :

Abo, K.A., Adeyemi A.A., and Jegede I.A,(2007) Cassia alata and Cassia occidentalis for Anthraquinone Content and Antimicrobial Activity - : -

Preetha, A and Banerjee, R,(2005) Comparison of Artificial Saliva Substitutes. Trends Biomaterial Artificial Organs - : -

Price. R.B.T. ,(2000) The pH of Tooth-Whitening Products - : -

Idson, B., and Lazarus, J,(1994) Theory and Practice of Industrial Pharmacy - : -

Chitnis, V.S., Malshe, V.S., and Lalla. J.K,,(1991) Bioadhesive Polymers Synthesis, Evaluation and Aplication in Controlled Release Tablets - : -





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-07
  1. Pelepasan Dan Penetrasi Natrium Diklofenak Sistem Niosom Span 60 Dalam Basis Gel Hpmc 4000
  2. Pengaruh Formulasi Terhadap Efekifitas Antimikroba Ekstrak Etanol 70% Daun Cassia Alata Linn Pada Candida Albicans
  3. Effect Of Hpmc K4m On Lactobacillus Acidophillus Viability In Tablet Dosage Form
  4. Optimasi Mikrosfer Ovalbumin-alginat Yang Diproduksi Dengan Teknik Aerosolisasi
  5. Pengaruh Gliserin Dan Propilenglikol Terhadap Karakteristik Fisik, Kimia Dan Spf Sediaan Krim Tipe O/w Ekstrak Biji Kakao (theobroma Cacao L.) (kadar Ekstrak Kakao 10%, 15% Dan 20%)

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