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Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 2 / No. 2 / Published : 2013-12

TOC : 2, and page :9 - 22

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Original Article :

Karakterisasi proniosom ibuprofen-span 60-kolesterol yang dibuat dengan pelarut propanol dan fase air gliserol 0,1%

Author :

  1. Tutiek Purwanti*1
  2. Dewi Melani Hariyadi *2
  3. Rio Pranata Hardjakusuma*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Mahasiswa Fakultas Farmasi

Abstract :

The aim of this study was to determine characteristic of ibuprofen which consist of  ibuprofen - Span 60 - cholesterol with molar ratio 2:1:0,75, 2:1:1, and 2:1:1,25. There were three formula this study. Evaluation of each formula were included by organoleptics (odor, colour, and consistency), proniosome morphology using light microscope, niosome morphology using Scanning Electron Microscope (SEM), niosome size used Particle Analyzer, and drug entrapment. Results of organoleptic tests were formula had propanol odor, white colour, and solid consistency. Evaluation used light microscope at 1000x magnification showed spherical shapes that had light edges. The next observation was Scanning Electron Microscope (SEM) up to 40000x magnification. Niosome size resulted 692 nm (formula I), 957,6 nm (formula II), and 1152,3 nm (formula III), for % drug entrapment, the result was 91,91 ± 1,12 (formula I), 88,41 ± 3,10 (formula II), and 89,84 ± 1,71 (formula III). The best formula was formula I because of smallest size, biggest entrapment, and high homogenity than other formula.

Keyword :

proniosome, ibuprofen, niosome, drug entrapment,


References :

  1. Biju, S.S., Talegaonkar, S., Mishra, P.R., and Khar, R.K, (2006). Vesicular systems : An overview. . India : Indian Journal of Pharmaceutical Sciences
  2. Chavan,P, (2011). Proniosomal Gel : A novel Approach for Transdermal Drug Delivery. India : . International Journal of Pharmaceutical Research and Development


   


Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-12
  1. Pengaruh kecepatan pengadukan terhadap karakteristik fisik mikrosfer ovalbumin-alginat dengan metode aerosolisasi
  2. Karakterisasi proniosom ibuprofen-span 60-kolesterol yang dibuat dengan pelarut propanol dan fase air gliserol 0,1%
  3. Aktivitas antibakteri sel amobil streptomyces griseus atcc 10137 dalam matriks poliakrilamid terhadap staphylococcus aureus atcc 25923
  4. karakterisasi sediaan, pelepasan dan uji penetrasi natrium diklofenak dengan sistem mikroemulsi dalam gel hpmc 4000
  5. Perbandingan aktivitas sitotoksik senyawa 1-(4-klorobenzoiloksi)urea dan 1-(4-metilbenzoiloksi)urea