UNIVERSITAS AIRLANGGA



Detail Article

Journal Of Emergency

ISSN 2301-7864

Vol. 2 / No. 1 / Published : 2013-07

Order : 5, and page :30 - 35

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Original Article :

Diagnostic test of serum glial fibrilary acidic protein for differentiating intracerebral hemorrhage stroke and non hemorrhage / ischemic stroke in acute stroke patients

Author :

  1. Yudityarini Priyanto*1
  2. Hendro Susilo*2
  1. Mahasiswa
  2. Dosen

Abstract :

Background: The rapid differentiation between intracerebral hemorrhage (ICH) and ischemic stroke using biomarker testing would allow cause-spesific management of stroke patient. Head CT Scan  is a gold standart for stroke but its still a rare examination of the area and require a relatively high cost. Glial fibrillary acidic protein (GFAP) is a brain-spesific astrocytic protein which identified as a promising biomarker in acute stroke patients. Objective: This study aimed to assess the sensitivity and specificity serum GFAP for differentiating intracerebral hemorrhage and ischemic stroke in acute stroke patients. Design of study: This is a clinical study, cross sectional analytical, and diagnostic test design. The design are performed on all patients who are diagnosed as acute stroke patients in Dr. Soetomo General Hospital Surabaya from October 2012 to January 2013. Methods: There were 73 subjects who met the inclusion criteria, conducted serum GFAP and head CT Scan, then analyzed by the Chi-square test 2 x 2 tables. Results: The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and likelihood ratio of serum GFAP of head CT scan are 85.7%, 64.4%, 60%, 87.9%, 72.6% and 2.41. Conclusions: serum GFAP have high sensitivity for differentiating intracerebral hemorrhage stroke and ischemic stroke in acute stroke patients.

Keyword :

diagnostic test, serum GFAP, head CT scan, acute stroke patients,


References :

Wunderlich MT, Wallesch CW, Goertler M,(2006) Release of Glial Fibrilary Acidic Protein is related to the neurovascular status in acute ischemic stroke Amerika Serikat : J Neurol

Wei JW, Arima H, Anderson CG,(2010) Significance of Perihematomal in Acute Intracerebral Hemorrhage London : European Neurological Journal





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-12
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  2. The Effect Of Fat Tissue Mesenchymal Stem Cells To The Total Amount Of Receptor Of Basic Fibroblast Growth Factor (bfgf) In Wound Healing Process On Males Rabbit (oryctolagus Cuniculus)
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  4. Lactate Levels, Deficit Bases, And Metabolic Acidosis Measures As Predictors Factor Laparotomy In Patients With Blunt Abdominal Trauma Fast Positive At Emergency Department Of Soetomo General Hospital Surabaya
  5. Relationship Between Intraoculi Pressure, Intracranial Pressure And Mean Arterial Pressure On Severe Brain Injury Patients
  6. Diagnostic Test Of Serum Glial Fibrilary Acidic Protein For Differentiating Intracerebral Hemorrhage Stroke And Non Hemorrhage / Ischemic Stroke In Acute Stroke Patients
  7. Effect Of Enteral Glutamine Supplementation For The Low Birth Weight On Gaining Weigh Pattern And Level Of Faecal Secretory Iga
  8. Correlation Between Body Mass Indeks And Incidence Of Hypotension On Pregnant Mothers Undergoing Caesarean Section Under Spinal Block Anesthesia
  9. Analysis Of The Level Of Rationality Of Blood Tranfusion In Emergency Surgery Serviced In The Emergency Department Soetomo General Hospital Surabaya

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