UNIVERSITAS AIRLANGGA



Detail Article

Journal Of Emergency

ISSN 2301-7864

Vol. 2 / No. 1 / Published : 2013-12

Order : 2, and page :10 - 18

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Original Article :

Effect of adipose mesenchymal stem cells on angiogenesis process on rabbit skin wound

Author :

  1. David S Perdanakusuma *1
  2. Sitti Rizaliyana*2
  3. Abda Arif*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Background : Wound healing is a complex process involving the orchestrated integration of cell migration, cell proliferation, and extracellular matrix to proceed trough three phases-inflamation, proliferation, and maturation. Dysregulation of this process leads to problem such as excessive healing in the form of keloids and hypertropic scars and chronic, nonhealing wounds. One of the most important factor in wound healing is angiogenesis. Stem cells offer enormous potential for enhancing tissue repair and regeneration. The earlier studies suggest that adipose mesenchymal stem cells can stimulate the production and secretion of growth factors, include transforming growth factor β (TGF-β), vascular endothel growth factor (VEGF), hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF). The aim of study is to verify the effects of adipose mesenchymal stem cells on increase of lumen vessels on rabbit skin wound . Methods : Experimental research design using post test only control group design 18 healthy male New Zealand white rabbit (Oryctolagus cuniculus). Full thickness wounds were made by 1 x 1cm at the  left and right back side, nearly 10 cm from the skull. The skin tissue specimen for histopatology examination taken on day 3, 14, and 21 after treatment with 5 x 106 adipose mesenchymal stem cells. Result : On all the wounds in wich were applied topical derived mesenchymal stem cells, the number of lumen vessel at inflammatory phase, proliferation phase, and maturation phase significantly higher with respect to the control (p<0,0001) and (p=0,010)

Keyword :

Wound healing, stem cells, lumen vessel, adipose mesenchymal,


References :

Judd H,(2003) Wound Care made Incredibly Easy 30-34 : Lippincott Williams & Wilkins





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-12
  1. The Effect Of Hyperthermia As A Remote Hyperthermic Preconditioning (rhp) On Viability Of Random Pattern Skin Flap In Rat
  2. The Effect Of Fat Tissue Mesenchymal Stem Cells To The Total Amount Of Receptor Of Basic Fibroblast Growth Factor (bfgf) In Wound Healing Process On Males Rabbit (oryctolagus Cuniculus)
  3. Effect Of Adipose Mesenchymal Stem Cells On Angiogenesis Process On Rabbit Skin Wound
  4. Lactate Levels, Deficit Bases, And Metabolic Acidosis Measures As Predictors Factor Laparotomy In Patients With Blunt Abdominal Trauma Fast Positive At Emergency Department Of Soetomo General Hospital Surabaya
  5. Relationship Between Intraoculi Pressure, Intracranial Pressure And Mean Arterial Pressure On Severe Brain Injury Patients
  6. Diagnostic Test Of Serum Glial Fibrilary Acidic Protein For Differentiating Intracerebral Hemorrhage Stroke And Non Hemorrhage / Ischemic Stroke In Acute Stroke Patients
  7. Effect Of Enteral Glutamine Supplementation For The Low Birth Weight On Gaining Weigh Pattern And Level Of Faecal Secretory Iga
  8. Correlation Between Body Mass Indeks And Incidence Of Hypotension On Pregnant Mothers Undergoing Caesarean Section Under Spinal Block Anesthesia
  9. Analysis Of The Level Of Rationality Of Blood Tranfusion In Emergency Surgery Serviced In The Emergency Department Soetomo General Hospital Surabaya

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