Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 40 / No. 1 / Published : 2004-01

Order : 3, and page :3 - 9

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Original Article :

Aquaporin water channels: physiology and medicine

Author :

  1. Harjanto*1
  1. Department of Physiology, Airlangga University School of Medicine

Abstract :

Aquaporins (AQPs) are a tetramer structure with independent channels. The structure was discovered in 1991 by Preston and Agre. The channels are widely expressed throughout the body. Currently there are at least 10 isoforms of AQPs recognized namely AQP (0-9). Primarily AQPs function as water channel and expressed at the sites where rapid fluid transport is to occur such as kidneys, lungs, brain, eyes and glands but there are exceptions. In addition to its function as water channel AQP-1 also transports CO2, AQP-3, AQP-7 and AQP-9 are also permeable to glycerol and transport other molecules. The permeability to glycerol is associated with gluconeogenesis process especially in fasting condition. The AQP-4 and AQP-0 are also proposed to function as part of cytoskeleton system and to be involved in cell adhesion The expression and function of AQPs are altered or modulated by many substances such as corticosteroid, vasopressin, ANP, secretin, lithium and HgCl2. AQPs expression and function are also altered by many conditions such as pH and electrolytes change, pregnancy, thirst, anemia, congestive heart failure, renal disease and liver cirrhosis. The defective expression and function of AQPs are also associated with several pathological events such as defective urinary concentrating ability, defective cerebral and lung water balance, defective saliva and sweat production, defective dietary fat processing, cataract, glaucoma and nephrogenic diabetes insipidus. The association between AQPs with many pathological events is hopefully providing alternative approach to elucidate and to solve many clinical problems.

Keyword :

structure, expression, functions, regulation, modulation, physiological, pathological,

References :

Cooper GJ, Zhou Y, Bouyer P, Grichtchenko II, Boron WF,(2002) Transport of volatile solutes through AQP- 1 - : Journal of Physiology

Agre P, King LS, Yasui M, Guggino WB, Ottersen OP, Fujiyoshi Y, Engel A, Nielsen S,(2002) Aquaporin water channels-from atomic structure to clinical medicine - : Journal of Physiology

Archive Article

Cover Media Content

Volume : 40 / No. : 1 / Pub. : 2004-01
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  2. Opinion: The Development Of Medical Education A Policy Analysis
  3. Aquaporin Water Channels: Physiology And Medicine
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