UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

Order : 1, and page :1 - 5

Related with : Scholar   Yahoo!   Bing

Original Article :

Correlation between dengue virus serotype and humoral immune response in pediatric dengue hemorrhagic fever

Author :

  1. Aryati*1
  2. Ety Retno Setyowati*2
  3. Agung Dwi Wahyu W*3
  1. Department of Clinical Pathology, Airlangga University School of Medicine
  2. Department of Clinical Pathology, Airlangga University School of Medicine
  3. Department of Microbiology, Airlangga University School of Medicine, Dengue Study Group, Institute of Tropical Disease, Airlangga University

Abstract :

Dengue hemorrhagic fever (DHF) is an endemic disease caused by dengue virus. The pathogenesis of dengue hemorrhagic fever is still unclear, while virus virulence and heterologous antibody still play important roles in the pathogenesis of dengue haemorrhagic fever. The aim of this study was to find the correlation between dengue virus serotype distribution and humoral immune response on dengue haemorrhagic fever in children. This infection pattern was based on the antibody profile as a humoral immune response in dengue virus infection. Dengue virus serotype examination was done by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), while humoral immune response was done by IgM-IgG Captured ELISA. The result of this study showed that from 35 dengue haemorrhagic fever cases, majority (74.4%) were secondary infection with mild gradation, grade I (48.6%) and grade II (34.4%). Den-3 and Den-4 serotypes were found, Den-3 have mild clinical manifestation, whereas Den-4 has a fatal manifestation as Dengue Shock Syndrome.

Keyword :

Humoral immune response, DHF, DSS, Den,


References :

Gubler DJ,(1998) Dengue and dengue hemorrhagic fever anonim : Clinical Microbiology Review

Halstead, SB,(1993) Pathophysiology and pathogenesis of dengue haemorrhagic fever WHO : Monograph on Dengue/Dengue Fever Haemorrhagic Fever





Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2008-01
  1. Correlation between dengue virus serotype and humoral immune response in pediatric dengue hemorrhagic fever
  2. Modulation of immunoglobulin g (igg) and cortisol responses in breathing exercise
  3. Prediction of distribution pattern of aedes aegypti as dhf main vector in jember
  4. Difference of interferon gammalevel (release assay) in nurses exposed to mycobacterium tuberculosis and active tuberculous patients
  5. Molecular expression of estrogen receptor alpha (erα) and interleukin 6 (il-6) on acceleration of healing process of long bone shaft fracture by immediate repetitive axial compression tension stabilization (ireact)
  6. Il-4 in peripheral blood mononuclear cells and bronchoalveolar lavage patients with pulmonary tuberculosis before and after treatment with oral anti-tuberculosis drugs
  7. Effect of oral curcumin and immobilization on the diameter of skeletal muscle fiber in rattus norvegicus
  8. Contralateral renal fibroblast and tubular cell apoptosis and proliferation in artificial unilateral total urethral obstruction in rabbits
  9. Polymorphism c3435t of the mdr-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer with her2/neu expression
  10. Review article:challenge of environmental toxicology in reformation era
  11. Bone morphogenetic protein 4 (bmp4) and prostaglandin alpha (pge2α) molecular expression in healing process acceleration of long bone shaft fracture using immediate repetitive axial compression tension stabilization (ireact)
  12. Treatment response of chronic myelogenic leukemia in dr. soetomo hospital
  13. Review article and clinical experience:the obesity pandemic: the “time-bomb disease” in the future?where have we been? and what should we do?

Information FMI