UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 4 / No. 1 / Published : 2015-06

Order : 7, and page :37 - 43

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Original Article :

Immunomodulator effect of sambiloto (andrographis paniculata) to total and differential counting of leucocytes in mice (mus musculus) exposed to heat stress

Author :

  1. Bunga Setha Vigirlia*1
  2. Dewa Ketut Meles*2
  3. A.T. Soelih Estoepangestie2*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to know the effective dos toe of sambiloto extract  to stabilizing total and differential counting leucocytes in mice exposed to heat stress. Thirty mice divided into five experimental groups, that were K(-), P0, P1, P2 and P3. All groups except K(-), were exposed to heat stress twice a day for thirty minutes in a temperature of 39-40oC with fifteen minutes interval in three consecutive days. P1, P2 and P3 was given sambiloto extract for ten days in different doses, which were P1 with 3.54 mg/20 g BW/day; P2 with 5.46 mg/20 g BW/day; P3 with 7.40 mg/20 g BW/day; and followed by heat stress exposure in the last three days. Total and differential counting leucocytes in blood was performed on the day after the last treatment. Statistical analyses used in this research were one way ANOVA and continued by Tukey Test. The result of the research showed there were significant differences (p<0.05) within the number of total leucocytes and lymphocytes and no significant difference (p>0.05) within the number of eosinophiles, basophiles, neutrophiles and monocytes.    

Keyword :

Sambiloto (Andrographis paniculata), mice, heat stress, total and differential counting leucocytes,


References :

Neal, M. J.,(2002) Medical Pharmacology at a Glance . Fourth Edition : Wiley-Blackwell.

Prapanza. I., Marianto, dan A. Lukito. . ,(2003) Khasiat dan Manfaat Sambiloto: Raja Pahit Penakluk Aneka Penyakit. 1-17 : Agromedia Pustaka. Jakarta.

Wibudi, A. ,(2006) Mekanisme Kerja Sambiloto (Andrographis paniculata NAP) Sebagai Anti Diabetes. 62 : [Disertasi]. Bogor: Sekolah Pascasarjana IPB.





Archive Article

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Volume : 4 / No. : 1 / Pub. : 2015-06
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  2. The Effect Combination Of Guava Leaf (psidium Guajava L.) And Sambiloto Leaf (andrographis Paniculata) On Total And Diffcount Leucocyte Of Mice (mus Musculus) Exposed To Heat Stress
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  7. Immunomodulator Effect Of Sambiloto (andrographis Paniculata) To Total And Differential Counting Of Leucocytes In Mice (mus Musculus) Exposed To Heat Stress
  8. Effect Of Guava Leaves (psidium Guajava L.) Extract On Total And Differential Count Of Leucocytes In Mice (mus Musculus) Exposed To Heat Stress
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