UNIVERSITAS AIRLANGGA



Detail Article

Journal of Basic Medical Veterinary

ISSN 2302-6820

Vol. 2 / No. 2 / Published : 2013-12

Order : 2, and page :130 - 136

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Original Article :

The effect of cosmos caudatus leaf ethanol extract in liver on paracetamol induced elevation sgot and sgpt in balb/c mice

Author :

  1. Gretania Residiwati*1
  2. Hani Plumeriastuti*2
  3. Sri Agus Sudjarwo *3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Pet animals and humans are at risk for developing toxicosis of drugs, include paracetamol that caused hepatic function as a major problem in the health world till now. One of Indonesian plant that is familiar with high content of flavonoid is Cosmos caudatus. The purpose of this study was to know the effect of Cosmos caudatus leaf ethanol extract especially as a hepatoprotector with preventing the elevation level of SGOT / AST enzyme and SGPT / ALT enzyme in the blood of male BALB/c mice that were exposed by paracetamol. 20 male BALB/c mice were divided randomly into four treatment groups as follows; P1: were given 1 ml/kg BW of CMC Na 1% suspension daily, P2: were given 1 ml/kg BW CMC Na 1% suspension daily and 1 g/kg BW of paracetamol on the 14th day, P3: were given 400 mg/kg BW of Cosmos caudatus leaf extract and 1 g/kg BW of paracetamol on the 14th day, P4: were given 800 mg/kg BW of Cosmos caudatus leaf extract and 1 g/kg BW of paracetamol on the 14th day of treatment. From the result, the maximum ability of Cosmos caudatus leaf extract in dose of 400 mg/kg BW and 800 mg/kg BW as hepatoprotector for preventing the elevation of SGOT (serum glutamate oxaloacetat transaminase) / AST enzyme and SGPT (serum glutamate pyruvat transaminase) / ALT enzyme level in blood of male BALB/c mice that were exposed by paracetamol can’t be seen well because of the less of the control and induced group for their ability as a standard parameters.

Keyword :

Cosmos caudatus, paracetamol, SGOT / AST enzyme level, SGPT / ALT enzyme level,


References :

Heryani. ,(2010) Aktivitas Fraksi Polifenol Buah Delima (Punica granatum L.) terhadap Peroksidasi Lipid Darah Tikus yang Diinduksi Parasetamol [Thesis]. Bogor : Mathematics and Science Faculty, Bogor Agricultural Institute.

Azam, M.G. and S. S. Haider. ,(2008) Evaluation of Dissolution Behavior of Paracetamol Suspensions. Dhaka : Dhaka Univ. J. Pharm. Sci. 7(1): 53-58.





Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2013-12
  1. Ldl Cholesterol Levels Of Male Rats (rattus Norvegicus) After Trans Fatty Acid In Margarine And Shorthening Consumption
  2. The Effect Of Cosmos Caudatus Leaf Ethanol Extract In Liver On Paracetamol Induced Elevation Sgot And Sgpt In Balb/c Mice
  3. Cholesterol Ldl White Mouse (rattus Novergicus) Levels Given Trans Fatty Acids From Margarine, White Butter And Waste Cooking Oil
  4. Time Patern Of Curcuma Zedoaria Etract Against Amount Of Mice Pulmonary Nodules Indusced By Benzo(α)pyrene
  5. The Effect Of Meniran (phyllanthus Niruri Linn) Infusion On Kidney Histopathological Overview Of White Rats (rattus Norvegicus) Exposed By Alkohol
  6. The Effect Of Giving Gossypol In (gossypium Hirsutum) To Cricket As Natural Insect Killer
  7. Antibacterial Potential Of Infusum Salak ( Salacca Zalacca ) To Staphylococcus Aureus And Escherichia Coli An In Vitro
  8. In Vitro Cytotoxic Effects Of Rosella Extract (hibiscus Sabdariffa) Against Myeloma Cell Culture

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