Jurnal Ilmiah Biologi FST
ISSN 2303-3428
Vol. 1 / No. 1 / Published : 2013-01
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Original Article :
Uji toksisitas subkronik polisakarida krestin dari ekstrak coriolus versicolor terhadap kadar sgpt mus musculus l.
Author :
- Ariesta Adriana Sagita*1
- Sri Puji Astuti Wahyuningsih*2
- Saikhu Akhmad Husen*3
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Abstract :
Coriolus versicolor contained polysaccharide krestin (PSK). Recent studies demonstrated that PSK could be immunomodulator. But PSK contained poison. This research evaluated the effect of subchronic toxicity of PSK to SGPT levels on mice. Polysaccharide krestin was administrated for 62 days by gavage which divided by 4 groups: P0 is control, P1 1,5 mg/kg of body weight, P2 3 mg/kg of body weight, and P3 6 mg/kg of body weight. After that, blood was taken for measuring SGPT levels. Data analyzed by One Way Anova and Duncan test with α = 5%. The result of this research showed that there was not difference of SGPT levels between control group and treatment group. The conclusion of the reasearch that PSK was not influence the level of SGPT on mice.
Keyword :
polysaccharide krestin, Coriolus versicolor, subchronic toxicity test, hepatocyte damage, SGPT,
References :
Cui, J. dan Christi, Y.,(2003) Polysaccharopeptides of Coriolus versicolor: Physiological Activity, Uses and Production - : Biotechnology Advances 21: 109-122
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Hosokawa, M., Mizukoshi, T., Sugawara, M., dan Kobayashi, H.,(1985) Thearapeutic Effect of PSK and Busulfan on the Recurrent and Metastatic Disease After the Surgical Removal of 3-Methylcholanthrene-Induced Tumors in Autochthonous C57BL/6 Mice When Administrated in Conjunction with Chemothearapy or Surgery - : Recent Advances in Chemotherapy, Anticancer Section, 2:768-769
Lu, F. C.,(1995) Toksikologi Dasar: Asas, Organ Sasaran dan Penilaian Resiko Jakarta : Edisi Kedua, UI Press, Jakarta
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