UNIVERSITAS AIRLANGGA



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VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 1 / No. 2 / Published : 2013-06

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Original Article :

The effect of pomegranate extract (punica granatum linn) on blood sodium and potassium levels of white rats (rattus norvegicus) with impaired nephrotoxicity by gentamicin-induced

Author :

  1. Bambang Sektiari Lukiswanto*1
  2. Wiwik Misaco Yuniarti*2
  3. Dinda Retno Anggraeni*3
  4. Agus Sunarso*4
  5. AT Soelih Estoepangestie*5
  1. Department of Clinical Science Faculty of Veterinary Medicine Airlangga University
  2. Department of Clinical Science Faculty of Veterinary Medicine Airlangga University
  3. Student of Veterinary Medicine
  4. Department of Veterinary Parasitology Faculty of Veterinary Medicine Airlangga University
  5. Department of Veterinary Public Health Faculty of Veterinery Medicine Airlangga University

Abstract :

This research was aimed to know the effect of pomegranate extract on the levels of sodium and potassium in the blood of white rats (Rattus norvegicus) with impaired nephrotoxicity by gentamycin-induced. 24 male rats 2-3 months old with 150-200 gram body weight were grouped into four different treatment for seven days followed: P0 group as a control group treated with CMC Na 0,3% and saline, P1 group treated with gentamycin and CMC Na 0,3%, P2 group treated with gentamycin and ellagic acid in CMC Na 0,3%, P3 group treated with gentamycin and pomegranate extract in CMC Na 0,3%. After seven days treatment, blood sample taken with intracardiac method. The levels of sodium and potassium in the blood were than measured using electrolyte analyzer with ion selective electrode method (ISE). Based on the result of the analysis of variance (ANOVA) and Duncan test, sodium test showed P0 has the significant effect to P1 but not significant with P2 and P3, and potassium test showed no significant result. The pomegranate treated group (P3) gave the best value on the levels of  sodium and potassium in blood, it gave a good effect in preventing nephrotoxicity in white rat.

Keyword :

Pomegranate extract, Nephrotoxicity, Blood potassium, Blood sodium, Gantamicin-induced,


References :

Avdagic N., Cosovic E., Nakas E., Mornjakovic Z., Hadzovic A., Zaciragic A,(2008) Spirulina Platensis Protects Against Renal Injury in Rats with Gentamicin-induced Acute Tubular Necrosis Bosnian : Bosnian journal of basic medical sciences: 8 (4): 331-336.

Lakshmi M., Reddy U.K., Rani S,(2012) A Review on Medicinal Plants For Nephroprotective Activity Tokyo : Asian Journal of Pharmaceutical and Clinical Research Vol 5, Issue 4,

Padmini M.P. and Kumar J.V,(2012) A Histopathological Study on Gentamycin Induced Nephrotoxicity in Experimental Albino Rats. London : IOSR Journal of Dental and Medical Sciences. Volume 1, Issue 1: 14-17

Seeram N.P., Adam L.S., Henning S.M., Niu Y., Zhang Y., Nair M.G., Heber D,(2005) In vitro antiproliferative , apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juic New York : J of Nutr Biochem 16:360-367.

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Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2013-01
  1. The Effect Of Pomegranate Extract (punica Granatum Linn) On Hepatic Histopathology Of Nephrotoxicity White Rats (rattus Norvegicus) Induced By Gentamicin
  2. The Effect Of Pomegranate Extract (punica Granatum Linn) On Blood Sodium And Potassium Levels Of White Rats (rattus Norvegicus) With Impaired Nephrotoxicity By Gentamicin-induced
  3. The Effect Of Pomegranate Extract On Blood Urea Nitrogen (bun), And Creatinin Serum In White Rat (rattus Norvegicus) Acute Renal Failure Processes
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