UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 1 / No. 2 / Published : 2013-06

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Original Article :

The effect of pomegranate extract on blood urea nitrogen (bun), and creatinin serum in white rat (rattus norvegicus) acute renal failure processes

Author :

  1. Chory Pudji *1
  2. Bambang Sektiari Lukiswanto*2
  3. Wiwik Misaco Yuniarti*3
  4. Pudji Srianto*4
  5. Daddy Sugianto Nazar*5
  1. Student of Veterinary Medicine
  2. Department of Clinical Science Faculty of Veterinary Medicine Airlangga University
  3. Department of Clinical Science Faculty of Veterinary Medicine Airlangga University
  4. Department of Veterinary Reproduction Faculty of Veterinary Medicine Airlangga University
  5. Department of Animal Science Faculty of Veterinary Medicine Airlangga University

Abstract :

The purpose of the research was to determine pomegranate extract effect in white rats (Rattus norwegicus) as an animal model of acute renal failure to decrease blood urea nitrogen  (BUN) and creatinine serum. Twenty four male rats at two to three months old with 150-200 gram of body weight, that were grouped into four different treatments. P0 group was a control group with 0.3% CMC Na 2 ml given orally, P1 group was given by 0.3% CMC Na 2 ml orally and gentamicin 80 mg/kg intraperitoneal, P2 and P3 groups were given by ellagic acid (EA) 60 mg/kg intraperitoneal and pomegranate extract (Punica granatum linn) 150 mg/kg intraperitoneal respectively in 0.3% CMC Na 2 ml in orally and gentamicin 80 mg/kg intraperitoneal. After seven days treatment, blood sample taken with intracardiac method, and then blood processing BUN and creatinine test using Berthelot and Jaffe method to examine the value of BUN and cratinine levels. The result showed that there were significant differences between each treatment group. P0 group had significantly different results with the P1 and P2 groups (p <0.05) but not significantly different from P3 (p> 0.05). The conclusion of the researched BUN and serum creatinine levels indicated there were influence of pomegranate fruit extract to decrease serum levels of BUN and creatinine in process white rat acute renal failure.

Keyword :

Blood Urea Nitrogen, Creatinin, Ellagic Acid, Pomegranate Extract,


References :

Bijanti R., M.G.A Yuliani., R.S Wahjuni., R.B Utomo,(2010) Buku Ajar Patologi Klinik Veteriner Surabaya : Airlangga University Press

Tessy Agus,Ardaya,Suwanto,(2001) Buku Ajar Ilmu Penyakit Dalam;Infeksi Saluran Kemih Jakarta : FKUI

Seeram NP,RN Schulman, D Heber,(2006) Pomegranate Ancient Roots to Modern Medicine New York : 1st Ed. Taylor and Francis Group, pp 2-99.

Sumaryono,(2007) Analisis Urea dan Kreatinin Tikus Putih Pasca Pemberian Ekstrak Mahkota Dewa dan Herba Pegagan Jakarta : Pusat Farmasi dan Fakultas Farmasi Universitas Pancasila

Zhang Y.,D Wang ., R Lee.,S.M Henning., and D Heber.,(2009) Absence of pomegranate Ellagitannins in the majority of commercial pomegranate extract : implication for standardization and quality control London : J. Agric. Food Chem 57: 7395-7400





Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2013-01
  1. The Effect Of Pomegranate Extract (punica Granatum Linn) On Hepatic Histopathology Of Nephrotoxicity White Rats (rattus Norvegicus) Induced By Gentamicin
  2. The Effect Of Pomegranate Extract (punica Granatum Linn) On Blood Sodium And Potassium Levels Of White Rats (rattus Norvegicus) With Impaired Nephrotoxicity By Gentamicin-induced
  3. The Effect Of Pomegranate Extract On Blood Urea Nitrogen (bun), And Creatinin Serum In White Rat (rattus Norvegicus) Acute Renal Failure Processes
  4. Antibiotic Susceptibility Of Pseudomonas Aeruginosa Strains Isolated From Dogs With Otitis Externa On Animal Clinic And Veterinary Practice In Surabaya
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  6. Incidence Of Scabies In Dogs At Some Veterinary Hospital And Animal Clinics In Surabaya From January-december 2012
  7. Infection Of Dipylidium Caninum In Cat
  8. Prevalence Of Feline Sarcoptic Infestation Of Cat Skin Diseases At Veterinary Teaching Hospital Airlangga University In 2012
  9. Antibiotic Susceptibility Of Staphylococcus Aureus Bacteria Isolated From Ear Swab Affected Dogs Otitis Externa