UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Ners

ISSN 1858-3598

Vol. 9 / No. 2 / Published : 2014-10

Order : 14, and page :270 - 278

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Original Article :

Hepatoprotective potential of propolis toward hepar injury rats (rattus norvegicus) induced by carbon tetrachloride

Author :

  1. Diah Krisnansari*1
  2. Hidayat Sulistyo*2
  3. Wahyu Dwi Kusdaryantoi*3
  1. Jurusan Kedokteran Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
  2. Jurusan Kedokteran Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
  3. Jurusan Kedokteran Fakultas Kedokteran dan Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman

Abstract :

Introduction: The prevalence of chronic liver disease continues to increase. One potentially hepatotoxic substances that cause chronic liver disease is carbon tetrachloride. The process of liver damage can be prevented by the antioxidant role of propolis. The aims of this research was to study the hepatoprotective potential of propolis toward hepar injury rats induced by carbon tetrachlorida. Method: This was an experimental study with pre-post test. Twenty five male Wistar rats aged 12-16 week old, weighing 125-200 gr were allocated into 5 groups. Group I : standard meal + aquadest-gavage; group II : standard meal + CCl4 1% 1 mL + aquadest-gavage, group III : standard meal + CCl4 1% 1 mL + 0,054 gr propolis-gavage, group IV : standard meal + CCl4 1% 1 mL + 0,108 gr propolis-gavage and group V : standard meal + CCl4 1% 1 mL + sylimarin 50 mg/kg-gavage. IL-6, SOD, NAS score+fibrotic were measured after treatment. Analysed of IL-6 and NAS score+fibrotic with Kruskal Wallis to Mann Whitney and analysed of SOD with One-Way ANOVA to LSD. Results: The study showed that there were significant differences in IL-6, SOD and NAS score + fibrotic between groups. Discussion: Provision of  0,054 gr and 0,108 gr have  hepatoprotective potential toward hepar injury rats induced by carbon tetrachlorida. Further research need to identify antioxidants and hepatoprotective potential of propolis on human with liver disease.

Keyword :

IL-6, SOD, fibrotic, propolis,


References :

Alvina,(2010) Type IV Collagen As Marker Of Fibrosis In Nonalcoholic Liver Disease - : Universa Medicina

Depkes, RI.,(2007) Profil Kesehatan Indonesia Jakarta : Depkes, RI.





Archive Article

Cover Media Content

Volume : 9 / No. : 2 / Pub. : 2014-10
  1. The Integrated Maternity Management Model Through Promoting And Preventive Encouragement In The Attempts Of Lowering The Maternal And Infant Mortality Rates
  2. Improving Counselling Skills About Reproductive Health Among Students Using Peer Counselor Training
  3. The Role Of Advanced Age And Duration Of Infertility On Oocyte Number Retrieved During In Vitro Fertilization
  4. The Resilience And Stress On Bacterial Vaginosis Among Reproductive Age Women In The Coastal Area Of Ampenan, Mataram City
  5. The Use Of Web-based Information System In Adolescents
  6. Rational-emotive Behavior Therapy Application Reduce Stress Among Mother With Leukemia Children
  7. Bio-psycho-social-spiritual Responses Of Family And Relatives Of Hiv-infected Indonesian Migrant Workers
  8. Decrease Risk Behavior Hiv Infected On Construction Laborers With Behavior Change Communication (bcc) Approach
  9. The Readiness Of Students To Learn Interprofessional Teamwork In Antenatal Care
  10. Nursing Care Model Based On Knowleedge Management In Preventing Nosocomial Infection After Sectio Caesarea In Hospital
  11. Holistic Learning Model Increase Asetilkoline Level And Caring Behavior On Student In Caring Patiens With Ischemic Stroke
  12. The Improvement Of Elderly Acceptance In Cronic Pain, Comfort, And Quality Of Life Through Acceptance And Commitment Therapy (act)
  13. The Effect Of Transcultural Nursing, Child Healthcare Model And Transtheoretical Model Approaches To Knowledge And Culture Of The Family
  14. Hepatoprotective Potential Of Propolis Toward Hepar Injury Rats (rattus Norvegicus) Induced By Carbon Tetrachloride
  15. Peer Group Support On Self-efficacy, Glicemic Control And Self Care Activities In Diabetes Mellitus Patients
  16. How Do Families Assess And Manage The Pain Of The Cancer Patients?
  17. The Improvement Of Low Salt Diet Behavior Based On Theory Of Planned Behavior On Elderly With Hypertension
  18. Sustainability Factor Related With The Implementation Of The Community Mental Health Nursing (cmhn) In South And West Jakarta
  19. Development Of Intention To Stay Model For Temporary Nursing Staff In Rs Unair
  20. A Study About The Quality Of Nursing Services At Hospitals’ Ward At Mojokerto
  21. The Competence Of Nurse Educators