Detail Article

Jurnal Urologi Universitas Airlangga

ISSN 23026480

Vol. 1 / No. 2 / Published : 2013-01

Order : 13, and page :13 - 13

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Original Article :

Masculinization in 46 xx congenital adrenal hyperplasia (cah) patient

Author :

  1. Dimas Sindhu Wibisono*1
  2. Ardy Santosa*2
  3. Tarmono*3
  4. no data*4
  5. no data*5
  1. no data
  2. no data
  3. no data
  4. no data
  5. no data

Abstract :

Introduction: Congenital adrenal hyperplasia (CAH) is the most common cause of ambiguous genitalia in the newborn and the most common cause of female pseudohermaphroditism. it is a classic example of an inborn error of metabolism (cortisol synthesis). divided into three categories: 1. salt wasters, 2. simple virilizers, 3. nonclassic patients. Case: We reported a 25 years old phenotype female 946 XX), with male sexual behavior and orientation which raised as a male. from physical examination we found 5cm of clitoris with severe chordee, normal internal genitalia, persistent urogenital sinus, perineal MUE, rugated major labia, and pubic hair. from chromosomal examination, there is mutation on gene CYP21A2. the patient two sisters also have the same abnormality. the patient has underwent chordectomy and planned to do urethroplasty on the next step of the operation. Conclusion: Most female with CAH has been treated medically by corticosteroid and perform feminizing genitoplasty. but in this case, the patient wanted to be a male. for the first step of operation, we have done chordectomy and for the next step we are planning to do urethroplasty. after the first operation, the patient have 8cm of "penis" with no complain of erection.

Keyword :

Congenital adrenal hyperplasia, female pseudohermaphroditism, cortisol synthesis, chordectomy, urethroplasty,

References :

Diamond DA,(2007) Sexual differentiation: normal & abnormal no data : Elsevier Science

Baskin SL,(2008) Abnormalities of sexual determination & differentiation no data : Mc Graw Hill

Moore LK, Persaud TVN,(2006) The urogenital system no data : Saunders

Naughton CK, Andriole GL,(2002) Adrenal tumors; management of urologic malignancies no data : Churcill Livingstone

Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2013-01
  1. Ureterovesical Junction Stenosis
  2. Pregnancy Rate, Semen Analysis And Varicocele Profile In Surabaya
  3. Enkrustasi Kateter Foley
  4. Tumor Retroperitoneum
  5. Divertikel Ureter
  6. Profile Urinalisis & Kultur Urine Pada Penderita Batu Ginjal Besar Multiple (batu Staghorn)
  7. Review Of Patients With Obstructive Uropathy Resulted From Malignancy In Gynecology At Dr. Soetomo Hospital Surabaya 2004-2007
  8. Gambaran Pasien Batu Ginjal Dan Batu Ureter Dengan Fungsi Ginjal Normal Yang Dilakukan Pemeriksaan Calcium, Asam Urat, Fosfat Dalam Darah Dan Urine Per 24 Jam Di Rsu Dr. Soetomo Surabaya, Januari - Desember 2006
  9. Testicular And Appendiceal Torsion
  10. Trends In The Diagnosis And Management Of Benign Hyperplasia Prostate In Indonesia
  11. Epididimo-orkitis Tuberkulosis
  12. Fournier's Gangrene
  13. Percutaneous Nephrolithotomy Procedures Profile In Dr. Soetomo General Hospital From January 2007 To June 2010
  14. Masculinization In 46 Xx Congenital Adrenal Hyperplasia (cah) Patient