Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)
ISSN 0852-1050
Vol. 5 / No. 3 / Published : 2005-12
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Original Article :
Aktivitas antimalaria ekstrak diklorometana kulit batang artocarpus champeden pada kultur plasmodium falciparum
Author :
- Nuri*1
- Yoes Prijatna Dachlan*2
- Noor Cholies Zaini*3
- Mulja Hadi Santosa*4
- Aty Widyawaruyanti*5
- Sjafruddin*6
- Bagian Ilmu Bahan Alam Program Studi Farmasi Universitas Jember
- Tropical Disease Centre Universitas Airlangga
- akultas Farmasi Universitas Airlangga
- Fakultas Farmasi Universitas Airlangga
- Fakultas Farmasi Universitas Airlangga
- Lembaga Biologi Molekuler Eijkman Jakarta
Abstract :
Artocarpus champeden has been used traditionally in Irian Jaya for the treatment of malaria. Scientific validation of this utilization was not previously made. The antimalarial activity of dichlorometane extract of A. champeden stem bark was tested against Plasmodium falciparum chloroquin-resistant strain (G2300) and chloroquin-sensitive strain (3D7) in vitro. The result showed that the dichlorometane extract of A. champeden stem bark inhibited the growth of P. falciparum chloroquin-resistant strain and chloroquin-sensitive strain with IC50 value 0,14432 μg/ml and 0,93633 μg/ml respectively.
Keyword :
Artocarpus champeden, antimalarial, Plasmodium falciparum,
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