UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 5 / No. 3 / Published : 2005-12

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Original Article :

Aktivitas antimalaria ekstrak metanol, fraksi dan isolat-isolat dari kulit batang cempedak (artocarpus champeden, spreng.)

Author :

  1. Maximus MT*1
  2. Gunawan*2
  3. Maria Nindatu*3
  4. Aty Widyawaruyanti*4
  5. Noor Cholies Zaini*5
  6. Yoes Prijatna Dachlan*6
  7. Sjafruddin*7
  1. Fakultas MIPA Universitas Katolik Widya Mandira Kupang
    Program Pascasarjana Universitas Airlangga Surabaya
  2. Program Pascasarjana Universitas Airlangga Surabaya
  3. Program Pascasarjana Universitas Airlangga Surabaya
    Fakultas MIPA Universitas Pattimura Ambon
  4. Fakultas Farmasi Universitas Airlangga, Surabaya
  5. Fakultas Farmasi Universitas Airlangga, Surabaya
  6. Tropical Desease Research Center Universitas Airlangga Surabaya
  7. Lembaga Biomolekuler Eijkman, Jakarta

Abstract :

This research was conducted to obtain the antimalarial active substance from methanol extract of A. champeden stem bark through the method of isolation guided by the antimalarial activity test at every level of methanol extract separations. The tests of antimalarial activity were done in-vitro with the non-synchronized culture of 3D7-strain of P. falciparum. Methanol extract has an antimalarial activity with the IC50 of 4.230μg/mL, and the active fraction showed the IC50 of 0.146μg/mL. The three amorphous isolates obtained from this active fraction showed the IC50 values of 0.052, 1.582, and 5.129μg/mL, respectively. With the same test condition, chloroquine diphosphate has the IC50 value of 0.003μg/mL. The result of identification of the three isolates demonstrated the existence of flavonoid compound contained in each isolate.

Keyword :

A. champeden, methanol extract, fraction and isolates, antimalarial activity, P. falciparum 3D7-strain.,


References :

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Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2008-01
  1. Uji Efektifitas Sediaan Gel Antiseptik Tangan Yang Mengandung Etanol Dan Triklosan
  2. Pengembangan Formula Sediaan Gel Antiseptik Tangan Ekstrak Daun Sirih (piper Betle Linn)
  3. Pengaruh Posisi Gugus Metoksi Para Dan Meta Terhadap Hasil Sintesis Asam Para-metoksisinamat Dan Asam Meta-metoksisinamat
  4. Aktivitas Antimalaria Ekstrak Metanol, Fraksi Dan Isolat-isolat Dari Kulit Batang Cempedak (artocarpus Champeden, Spreng.)
  5. Aktivitas Antimalaria Ekstrak Diklorometana Kulit Batang Artocarpus Champeden Pada Kultur Plasmodium Falciparum
  6. Uji Toksisitas Akut Dan Subakut Ekstrak Etanol Dan Ekstrak Air Kulit Batang Artocarpus Champeden Spreng Dengan Parameter Histopatologi Hati Mencit
  7. Pengaruh Ekstrak Etanol Dan Ekstrak Air Kulit Batang Artocarpus Champeden Spreng Terhadap Kadar Enzim Sgpt Dan Sgot Mencit.

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