Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 10 / No. 1 / Published : 2010-10

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Original Article :

Insulin like growth factor-1: briedging between phisycal exercise and bone density

Author :

  1. Neng Tine Kartinah Almuktabar*1
  1. Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

Abstract :

Physical excercise could increase bone density because there is osteogenesis as a adapatation respons. This effect is role of Insulin like Growth Factor-1 (IGF-1) hormone that a growth hormone dependent polypeptides. These polypeptides are produced both systemically (as endocrine productin) and localy as paracirine or autocrine. Endocrine production of IGF-I increase by physical excercise. The increasing this hormone  will increase growth hormone (GH) level, and will be bounded by GH receptor in liver. Growth hormone-receptor bounding will stimulate IGF-1 production signals. While the paracrine production of IGF-1 increased by mechanical strain due to strain on the bone will stimulate the formation of prostaglandins as a precursor to IGF-1. The IGF-1 is bound by its receptor and then will produce a series of tranduksi signal to the nucleus resulting in cell proliferation and differentiation of osteoblasts. The role of osteoblast cells is to synthesize matrix, bone collagen and stimulate replication of cells derived osteoblasts is osteosit. This will increase bone density

Keyword :

Physical exercise, IGF-1, bone density,

References :

Mundy GR,(1999) Primer on the metabolic bone disease and disorder of mineral, 4th ed Philadelpia : Lippicon william & wilkins

Archive Article

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Volume : 10 / No. : 1 / Pub. : 2010-10
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  5. The Effect Of Black Soybean Extract Supplementation In Low Density Lipoprotein Level Of Rats (rattus Novergicus) With High Fat Diet
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  9. The Difference Of Sweet Taste Sensitivity Because Of The Usage Of Non-alcoholic Mouthwash Compared With 26% Alcohol Contained Mouthwash
  10. Insulin Like Growth Factor-1: Briedging Between Phisycal Exercise And Bone Density
  11. The Influence Of High Fat Diet On Metabolic Syndrome Markers In Rats (sprague Dawley)
  12. The Effectiveness Of Guava Leaf Extract (psidium Guajava L.) On Erythrocytes Superoxide Dismutase Activity Sports Treated Rattus Norvegicus