UNIVERSITAS AIRLANGGA



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BIOSAINS

ISSN 1412-1433

Vol. 14 / No. 1 / Published : 2012-01

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Original Article :

Mechanism of hypersensitivity pneumonitis (hp) as a result from the exposure of dust from paddy milling on mice (mus musculus) balb/c

Author :

  1. Isa Ma’rufi *1
  2. Kuntoro*2
  3. Soedjajadi Keman*3
  4. JF. Palilingan*4
  1. Fakultas Kesehatan Masyarakat Universitas Jember
  2. Fakultas Kesehatan Masyarakat Universitas Airlangga
  3. Fakultas Kesehatan Masyarakat Universitas Airlangga
  4. Fakultas Kedokteran Universitas Airlangga

Abstract :

The purpose of this research was to analyze the immune response mechanism of Hypersensitivity Pneumonitis (HP) as a result fromthe exposure of dust from paddy milling on mice (Mus musculus)BALB/C. The research done was a laboratory experimental researchwith mice (Mus musculus) as experimental animal. The research design used was the post only control group design using mice (Musmusculus) Balb/c as experimental animal. Mice (Mus musculus) BALB/C were exposed to dust from paddy milling for four (4) hours/dayand it was done for thirty (30) days with the exposed concentrations respectively were 0.50 mg/m3, 0.75 mg/m3, 1.00 mg/m3.The researchvariables were free variable, dependent variable, and control variable. Independent variable was dust from paddy milling, dependentvariables were Hypersensitivity Pneumonitis (HP), IgE, IL-4, CD8, IFN-γ, infl ammatory cells, and histopathological picture of micelung, while control variables were strain, body weight and age of mice (Mus musculus) BALB/C. The research result showed that therewas an increased of IgE, yet statistically there was no signifi cant difference; there was an increase on IL-4, CD-8, IFN-γ, infl ammatorycells and lung histopathology and statistically there was a signifi cant difference between the study and control on mice BALB/C. Theconclusion of the research was that the immune response mechanism of Hypersensitivity Pneumonitis (HP) as a result from the exposureof dust from paddy milling on mice (Mus musculus) BALB/C. It could be concluded that dust from paddy milling inhaled repeatedlypassed into the alveoli and then it was caught by alveolar macrophages which then generated the increase of IL-4 and CD-8. Afterthat, IL-4 generated the increase of IgE which afterward attracted mast cells while CD8 expressed IFN-γ which then activated alveolarmacrophages and attracted a number of neutrophil and mast cell which subsequently induced infl ammation. The infl ammation occurredwould develop into other tissue damage and led to Hypersensitivity Pneumonitis (HP). It was suggested that: it be better to repeat withlonger exposure time so that the damage in lung be seen more clearly especially the occurrence of granuloma in lung.

Keyword :

Hypersensitivity Pneumonitis (HP), dust from paddy milling,


References :

Ancillo M, Domínguez-Noche C, Gil-Adrados AC, Cosmes PM,,(2004) Hypersensitivity pneumonitis due to occupational inhalation of fungicontaminated corn dust. - : J Invest Allergol Clin Immunol

Barrera L, Felipe M, Joaquı´n, Andrea E, Ana CZ, and Emma I,,(2008) Functional diversity of Tcell subpopulations in subacute and chronic hypersensitivity pneumonitis. - : Am J Respir Crit Care Med,

Cormier Y and Schuyler M,(2006) Hypersensitivity pneumonitis and organic dust toxic syndromes. In Bernstein L (ed). Asthma in the workplace, 3rd ed. New York : Taylor & Francis Goup.





Archive Article

Cover Media Content

Volume : 14 / No. : 1 / Pub. : 2012-01
  1. The Expression Of β Catenin And β4 Integrin In Aggressive And Non-aggressive Basal Cell Carcinoma
  2. Mechanism Of Hypersensitivity Pneumonitis (hp) As A Result From The Exposure Of Dust From Paddy Milling On Mice (mus Musculus) Balb/c
  3. Under Fives Nutritional Rearing Model Based On Risk Factors Approach
  4. Apoptosis Pneumocyte Type I & Ii On Lsbt Resuscitated Haemorrhagic Hypovolemic Shock Experimental Study On Rat Sprague Dawley
  5. The Effects Of Glutamine On Sucrase, Maltase, Lactase Activity And Spectrin, Clathrin Expression In Repairing Microvilli Ileum In Rats Malnutrition
  6. The Increased Expression Of L-type Calcium Channel, Protease Activating Receptor-1 And Heat Shock Protein-27 And Density Of Intracellular Calcium On Animal Model Of New Zealand Rabbit Myometrium That Using Conservative Surgical Procedure Of Surabaya Suture Compression Modification (biomolecular Study In Conservative Surgical Management Of Pph Due To Uterine Atony)

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