UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 7, and page :98 - 101

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Original Article :

Treatment response and acute toxicity evaluation of 70 gray radiation in nasopharyngeal carcinoma patients in dr soetomo hospital, surabaya

Author :

  1. Nyoman Satya *1
  2. H. Sugiarto Suwitodihardjo*2
  1. Department of Radiology, Negara Hospital, Jembrana, Bali
  2. Department of Radiology, Airlangga University School of Medicine, Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Nasopharyngeal carcinoma (NPC) is the most common malignancy of head and neck cancer in Indonesia. Radiotherapy is the mainstay of treatment for NPC. Usually external beam radiation treatment is performed with dose of 60-70 Gy. Result of irradiation treatment is influenced by some prognostic factors including gender, age, tumor stage, histopathologic and hemoglobin level. In addition to eradicate tumor cell, irradiation treatment also influences acute effect (acute toxicity) of normal tissue surrounding tumor as well as late effect. This study was performed with an observational cohort retrospective analysis, which analyzed 54 patients of NPC who had underwent irradiation with cumulative dose of 70 Gy for evaluating the correlation between some prognostic factors and treatment response, and for evaluating acute toxicity. There was positive correlation between tumor stage and irradiation treatment response, proven by Kruskal-Wallis statistic analysis (p = 0.021). Meanwhile, by using Fisher Exact one-tail method there were statistically significant association of irradiation treatment response between patient with stage III and stage IV (p = 0.035 and Odds Ratio = 10.8). The patient with stage III shows predominant risk to have complete response comparing with partial response which 10.8 times higher than those in stage IV. It indicated that dose given of 70 Gy for NPC patients in the early stage had a better treatment response. There were no significant correlation between sex, age, histopathologic and hemoglobin level with irradiation treatment response (p > 0.05). Radiation toxicity was calculated by LENT SOMA scale. Most radiation toxicity was acute with moderate toxicity (grade II).

Keyword :

NPC, prognostic factor, treatment response, radiation toxicity. ,


References :

Chong, VFH & Tsao, Y,(1997) Nasopharyngeal Carcinoma Singapore : Armour Publishing Pte Ltd.

Perez, CA,(1998) Nasopharynx, in Principles and Practice of Radiation Oncology, 3hd edn Philadelphia : JB Lippincot Company





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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