UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Oftalmologi Indonesia

ISSN 1693-2587

Vol. 5 / No. 3 / Published : 2007-12

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Original Article :

The comparison of tetracycline and doxycycline treatment on corneal epithelial wound healing in the rabbit acid-burn model

Author :

  1. Dwi Ahmad Yani*1
  2. Gatut Suhendro*2
  1. Department of Ophthalmology, Airlangga University/Dr. Soetomo Hospital Surabaya
  2. Department of Ophthalmology, Airlangga University/Dr. Soetomo Hospital Surabaya

Abstract :

Objective: To demonstrate the comparison of tetracycline and doxycycline in the treatment of corneal epithelial wound healing following acid burning. Material and Methods: Thirteen New Zealand white rabbits (2.5-3 kg) were divided in to three groups and received bilateral acid burns (1N sulfuric acid applied to 5.5 mm diameter circular disc of Whatman 41 filter paper for two minutes). In group 1, four rabbits (eight eyes) served as untreated control. In group 2, four rabbits (eight eyes) received tetracycline (50 mg/kg) orally daily for 14 days. In group 3, five rabbits (ten eyes) received doxycycline (5mg/kg) orally daily for 14 days. The reepithelization was monitored by means of fluorescein staining and slitlamp. Statistical analysis used were one-way annova and chi-square test with significancy of 0.05. Results: After 14 days, the mean diameters of corneal epithelial defect were 3.30 mm, 2.00, and 2.62 mm, respectively. The results of one-way annova test indicated that between the 5th until 10th day of observation, the mean diameters of corneal reepithelization in group 2 and 3 were found to be statistically significant (p

Keyword :

corneal epithelial wound healing, doxycycline, rabbit acid-burn model, tetracycline ,


References :





Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2008-12
  1. C Y T O K I N E S
  2. Skin Flap Pada Kelopak Mata
  3. Fitting Lensa Kontak Rigid Gas Permeable (rgp)
  4. Teknik Pembedahan Rekonstruksi Pasca Eksisi Tumor Ganas Kelopak Mata
  5. Diplopia Binokuler Akibat Paresis N Iii, Iv Dan Vi Di Rs Mata Dr. Yap Yogyakarta
  6. Comparison Of P53 Expression In Hpv(+) And Hpv(-) In Conjunctival And Eyelid Squamous Neoplasia
  7. The Comparison Of Tetracycline And Doxycycline Treatment On Corneal Epithelial Wound Healing In The Rabbit Acid-burn Model
  8. Dandy Walker Syndrome In 7 Month-old Boy
  9. Combination Of Cutler -beard Flap,v-y Glabellar Flap And Direct Closure For Large Resection Upper Eyelid And Medial Canthus
  10. Limbal Stem Cell Transplantation In Limbal Stem Cell Deficiency After Steven Johnson Syndrome
  11. Hypoglobus And Ptosis Reconstruction After Lacrimal Benign Mesenchymal Tumor Excision
  12. Association Between Refractive Changes And Blood Glucose Changes In Diabetic Mellitus Type 2 Patient
  13. Management Of The Complication After Silicone Fluid Injection At Facial And Eyelid Region
  14. The Difference Of Epidermal Growth Factor Concentration Between Fresh And Freeze-dried Amniotic Membranes
  15. Sindroma Laurence-moon-bardet-biedl
  16. Bilateral Orbital Apex Syndrome
  17. Clinical Difference Between Autograft Post Operated Pterygium Using Fibrin Glue And Polyglycolic Acid 10-0 Suture

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