UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Penelitian Medika Eksakta

ISSN 1411-6626

Vol. 7 / No. 1 / Published : 2008-04

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Original Article :

Efek sitotoksik in vitro dari ekstrak buah mahkota dewa (phaleria macrocarpa) terhadap kultur sel kanker mieloma

Author :

  1. Rochmah Kurnijasanti Kurnijasanti*1
  2. Iwan Sahrial Hamid*2
  3. Kadek Rahmawati*3
  1. Bagian Ilmu Kedokteran Dasar Veteriner FKH Universitas Airlangga
  2. Bagian Ilmu Kedokteran Dasar Veteriner FKH Universitas Airlangga
  3. Bagian Ilmu Kedokteran Dasar Veteriner FKH Universitas Airlangga

Abstract :

Cancer is still a fearful disease in the world and an ideal medicine has not been found yet. The fruits of mahkota dewa (Phaleria macrocarpa) have been reported to be used as an anticancer agent, however no scientific reports have been published so far. This study is aimed to test the cytotoxic effect of the mahkota dewa fruit’s on cell culture of myeloma in vitro.The mahkota dewa fruit’s were extracted with metanol. The extract were tested for its anticancer activity using viability test method on cell culture of myeloma. The myeloma cell were incubated in RPMI media contained 10% OF Fetal Bovine Serum (FBS). The concentration of extract mahkota dewa fruit’t were 5; 2,5; 1,25; 0,625 and 0,312 mg/ml. The metanol was used as solution control in five different concentration (10; 5; 2,5; 1,25 and 0,625, respectively) while RPMI was used as negative control. Their solution were added into myeloma cell culture in microwell plate and then incubated for 24 hours, at 37ºC in CO2 incubator. Determination of anticancer activity used trypan blue exclusion method, with parameter value was viability of myeloma cell.Analysis of varian of the data showed that extract mahkota dewa (Phaleria macrocarpa) fruit’s have anticancer activity against cell culture of mice myeloma. The highest of extract concentration (5 mg/ml) have destructed 24,75% myloma cells.

Keyword :

Citotoxicity effect, Mahkota Dewa Fruit’s, Myeloma cell,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2008-04
  1. Efek Pemberian Epinefrin Terhadap Hemoglobin, Jumlah Eritrosit Dan Retikulosit
  2. Perubahan Oral Flora Dan Sensitifitas Karies Gigi Anak Setelah Pengulasan Fluoride Secara Topikal
  3. Potensi Analgesik Dan Antiinflamasi Dari Ekstrak Tapak Liman (elephantophus Scraber)
  4. Efek Antinociceptif Gaba Agonis Gabapentin Terhadap Nyeri Neuropati Pada Hewan Coba Mencit
  5. Modifikasi Pati Singkong Pregelatin Sebagai Bahan Pembawa Cetak Langsung
  6. Efek Sitotoksik In Vitro Dari Ekstrak Buah Mahkota Dewa (phaleria Macrocarpa) Terhadap Kultur Sel Kanker Mieloma
  7. Pemberian Whole Serum Kuda Lokal Bunting Yang Disentrifugasi Dengan Charcoal Terhadap Birahi Dan Kebuntingan Pada Sapi Potong
  8. Inferensi Kurva Regresi Nonparametrik Berdasarkan Estimator Polinomial Lokal Dengan Error Lognormal
  9. Faktor-faktor Yang Mempengaruhi Perempuan Dalam Menghadapi Menopause
  10. Manipulasi Reproduksi Pada Itik Petelur Afkir Dengan Pregnant Mare Serum Gonadotropin

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