Jurnal Respirasi
ISSN 2407-0830
Vol. 1 / No. 2 / Published : 2015-05
Order : 1, and page :41 - 47
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Original Article :
Hubungan kadar interleukin-10 dan tuberkulosis multi-drug resistant
Author :
- Nurjanah Lihawa*1
- Resti Yudhawati, dr., Sp.P(K)*2
- Mahasiswa Fakultas Kedokteran
- Dosen Fakultas Kedokteran
Abstract :
Background :Prevalence of multi-drug resistant tuberculosis (MDR-TB) is increased by the time. In Indonesia, there were an estimated 1,9 % of new cases and 12% of previously treated cases. Protection against Mycobacterium tuberculosis is dependent on Th1 cell CD4+ that produced pro-inflammatory cytokines such as IFN-ɣ and TNF-α. T cell regulators (Tregs) produced IL-10 as anti-inflammatory cytokine is against the function of those pro-inflammatory cytokines. It is believed that immune suppression is responsible for MDR-TB. The previous study showed impaired Th1 responses and enhanced regulatory T-cell levels in circulatory blood of MDR-TB patients. The study of IL-10 represented anti-inflammation cytokine as immune suppression never been conducted in Indonesia.Objective :To analyze relationship between level of interleukin-10 and Multi-drug resistant tuberculosis. Methods :The study was conducted at the outpatient department of MDR-TB and DOTS of Dr.Soetomo hospital in Surabaya. Total sample was 38 of TB patients that consist of 19 MDR-TB patients (secondary resistant) and 19 non-MDR TB patients as control. Results : In this study we found that the median level of IL-10 as 5,7±3,3 pg/mL in the group of MDR-TB patients with minimum level was 1,3 pg/mL and maximum level was 14,0 pg/mL while median level of IL-10 in non-MDR TB patients was 7,0±3,4 pg/mL with 3,2 pg/mL and 16,5 pg/mL, respectively. To analyze correlation between time to first of having TB until became MDR-TB and level of IL-10 by using Pearson’s correlation, we showed that no statistical correlation (p>0,05). According to statistical classification, we found that no statistical correlation between level of IL-10 and the history of treatment in MDR-TB patients (p>0,05). Data showed that all the history of treatment classification dominated by MDR-TB patients with the low level of IL-10. We also found that no statistical difference with the level of IL-10 in MDR-TB and non-MDR TB patients (p>0,05) although in descriptive state we found the level of IL-10 was higher in non-MDR TB patients. And also there was no relationship between level of IL-10 and MDR-TB (p>0,05). It could be explained that the host factor was not involved and in the other side we still not known the factor of agents, yet. The low level of IL-10 that was observed in this study could be interfering by the strain of M.tb which not assessed in this study. Conclusion: In this study we found that level of IL-10 is not increase in MDR-TB patients and there was no relationship between level of IL-10 and MDR-TB (p>0,05
Keyword :
MDR-TB, anti-inflammation cytokines, IL.10,
References :
PDPI,(2011) Tuberkulosis. Pedoman Diagnosis dan Penatalaksanaan di Indonesia - : Perhimpunan Dokter Paru Indonesia
Skolimowska K, Rangaka M, Meintjes G, Pepper D, Seldon R, Matthews K, et al,(2012) . Altered ratio of IFN-gamma/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV-tuberculosis Immune Reconstitution Inflammatory Syndrome - : PLOS ONE
Archive Article
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 Volume : 1 / No. : 2 / Pub. : 2015-05 |
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