UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 2 / Published : 2009-10

Order : 2, and page :5 - 8

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Original Article :

efek agonis selektif reseptor opioid kappa u-50,488h pada perubahan morfologi neuronal refrontal cortex (pfc) dan nucleus accumbens (nac) mencit (mus musculus) yang mengalami ketergantungan morfin

Author :

  1. Toetik Aryani*1
  2. Nanik Widjayanti*2
  3. Junaidi Khotib*3
  1. Dosen Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

Repeated treatment of morphine produces several change in brain and behavior that far outlast their initial neuropharmacological effects. The nature of persistent drug-induced neural plasticity is of interest because it is thought to contribute to the development of drug dependency and addiction. To determine if chronic morphine treatment alters the morphology of prefrontal cortex (PFC) and nucleus accumbens (NAc), this study was designed to evaluate the effects of a selective kappa opioid receptor agonist U-50,488H on the morphological change of PFC and NAc neurons, we have used chronic morphine exsposure to leads dependency of mice. Mice were treated morphine with an escalating doses from 10 mg/kg  to 140 mg/kg. Mice receive morphine twice a day daily for a week. At 8th  of the day, mice were treated naloxone to precipitated withdrawal syndrome. U-50.488H dose 0.1; 1 and 3 mg/kg were administrated thirty minutes before injection of morphine. This observation shown that the increasing of locomotion reduced significantly by repeated administration of U-50,488H (F(4,49)) = 18.30 p = 0,001) and a significant reduction on the decreasing of weight (F(4, 49) = 3.360 p= 0.020). Furthermore, we observed that treatment of morphine produces the morphological change of PFC and NAc neurons, that was stained by hematoxylin-eosin. The changes are shape, size, density of neuron and apoptosis cell. Compared with  control mice, apoptosis cell of morphine-treated animals.

Keyword :

U-50, 488H, morphine dependence, withdrawal syndrome, morphology neuronal.,


References :

Adinoff, B,(2004) Neurobiologic processes in drug reward and addiction 12, p. 305-320 : Harv Rev Psychiatry

Irawati, D,(2006) Efektivitas antagonis dopamin dalam menurunkan gejala withdrawal pada mencit dengan ketergantungan morfin - : Skripsi Fakultas Universitas Airlangga, Indonesia

Nestler, E. J., and Carlezon, William,. A,(2005) The mesolimbic dopamine reward circuit in depression Vol 59, p. 1151-1159 : Journal of Biological Psychiatry.

Noble, Florence and Cox, Brain M.,(1997) The Role of Dopaminergic Systems in Opioid Receptor Desensitization in Nucleus Accumbens and Caudate Putamen of Rat After Chronic morphine Treatment 283 p. 557-565 : The Journal of Pharmacology and Experimental therapeutics





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2009-10
  1. Effect Of  U-50,488 H On The Development Of Drug Craving Behavioral And Protection Of Morphological Change In Prefrontal Cortex, Thalamus And Amygdale Of The Mice (mus Musculus)  In The Morphine-induced Dependence
  2. Efek Agonis Selektif Reseptor Opioid Kappa U-50,488h Pada Perubahan Morfologi Neuronal Refrontal Cortex (pfc) Dan Nucleus Accumbens (nac) Mencit (mus Musculus) Yang Mengalami Ketergantungan Morfin
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