UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 1 / Published : 2009-04

Order : 4, and page :17 - 21

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Original Article :

formulasi tablet hisap ekstrak teh hijau berbasis sorbitol dengan metode granulasi basah( pengaruh kadar pengikat methocel e-50 terhadap mutu fisik tablet )

Author :

  1. Khoirotin Nisak*1
  2. Bambang Widjaja*2
  3. M. Agus Syamsur Rijal*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The objective of this study was to determine the effect of Methocel E-50 concentration as tablet binder on physical characteristics of Green Tea Extract Lozenges. The tablet were prepared by the wet granulation method using three different concentration of Methocel E-50 0.5% (F2); 1% (F3); and 1.5% (F4). The granule were evaluated for flowability, angle of repose, and moisture content. A hydraulic press was used for tabletting at 1 ton pressure. The diameter of the die was 13 mm. The tablets were subjected to hardness, friability, and dissolving time evaluation. The granule showed acceptable result on flow properties, angle of repose and moisture content. From statistical analysis it could be seen that there were significant difference among formulas for the dissolving time, but there were no significant difference among formulas for tablet hardness and friability. The dissolving time of green tea extract lozenges was significantly enhance by increasing Methocel E-50 concentration. All formulas had fulfilled the requirements of lozenges specification. This observation suggest that sorbitol based green tea extract lozenges could be formulated without the addition of binding agent.

Keyword :

Green Tea Extract, Wet Granulation, Methocel E-50, Physical performance,


References :

Carstensen, J.T.,(1977) Pharmaceutics of Solids and Solid Dosage Form CANADA : John Willey & Sons, Inc

Ansel, H.C., N.G.Popovich, L.V. Allen,Jr,(1995) Pharmaceutical Dosage Form and Drug Delivery Systems 6th ed USA : Williams and Wilkins

Aulton, M.E., M. Summers,(2002) Granulation in: Aulton, M.E., Pharmaceutics The Science of Dosage Form Design 2nd ed London : Hartcourt Publisher Limited

Henning, S.M., Niu, Y., Lee, N.H., Thames, G.D., Minutti, R.R., Wang, H., Go, V.L.W., Herber, D,(2004) Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. - : Am J Clin Nutr.





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2009-04
  1. Analisis Terhadap Faktor-faktor Yang Mempengaruhi Kepatuhan Penggunaan Obat Asma Inhalasi
  2. Influence Of Β-cyclodextrin As An Inclusion Complexing Agent For The Solubility Of Mefenamic Acid In Base Solution
  3. Characterization Of Carbamazepine- Hydroxypropyl-β-cyclodextrin Inclusion Complex In Solid State Obtained By Freeze-drying Process
  4. Formulasi Tablet Hisap Ekstrak Teh Hijau Berbasis Sorbitol Dengan Metode Granulasi Basah( Pengaruh Kadar Pengikat Methocel E-50 Terhadap Mutu Fisik Tablet )
  5. Pengaruh Sirkadian Pada Farmakokinetik Sulfametoksazol Oral Dengan Data Darah Kelinci
  6. Pengaruh Penambahan Kulit Pisang Cavendish (musa Cavendishii) Terhadap Kualitas Minyak Kelapa Murni Yang Mengalami Pemanasan Ulang
  7. Pengaruh Pemberian Antagonis Reseptor N-metil-d-aspartat (nmda) Mk-801 Terhadap Penurunan Sensasi Nyeri Inflamasi

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