UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 1 / Published : 2009-04

Order : 8, and page :32 - 41

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Original Article :

pengaruh pemberian antagonis reseptor n-metil-d-aspartat (nmda) mk-801 terhadap penurunan sensasi nyeri inflamasi

Author :

  1. Rahmad Aji*1
  2. Lisa Gondo*2
  3. Junaidi Khotib*3
  4. Bambang SZ*4
  5. Imam Susilo2*5
  1. Mahasiswa Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi
  5. Mahasiswa Fakultas Farmasi

Abstract :

The present study was design to investigate the efficacy of a novel potent non-competitive N-Methyl-D-Aspartate (NMDA) receptor antagonist, MK-801, on the relieving inflammatory pain in mice. A model of inflammatory pain like state was induced by intraplantar injection of Complete Freund’s Adjuvant (CFA). NMDA antagonist MK-801 was administered intrathecally once a day for 7 consecutive days at 0.01, 0.10, 1.00, 10.00, or 20.00 nmol doses a week after CFA injection. Thermal hyperalgesia was measured on days 0, 1, 3, 5, 7, 8, 10, 12, 14, and 21 after CFA injection by warm plate. Paw thickness at the ipsilateral site was also measured on days 0, 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 14, and  21 after CFA injection. Histology of the spinal cord tissue was examined by light microscope following haematoxylline-eosin staining. The results showed that MK-801 given at 0.01-20.00 nmol dosage significantly increased mice’s latency on thermal stimulation compared with placebo (p<0.001). Paw thickness was also significantly decreased to compare with placebo after intrathecal injection of MK-801 at 0.01, 1.00 and 10.00 nmol dosage (p<0.001; p=0.005; p=0.015 respectively). Whereas MK-801 administration at 0.01, 1.00, and 20.00 nmol could decrease the inflmammatory cells infiltration and recover the dorsal horn histology compare with placebo. Taken together, these results show that MK-801 is effective in relieving the inflammatory pain.

Keyword :

Chronic pain, Inflammatory pain, MK-801, NMDA receptor,


References :

Suroto,(2006) Aspek Neurobiologi Nyeri dan Inflamasi. Dalam: Leksmono, P., Mohammad Saiful Islam, dan Yudha Haryono (Eds.). Kumpulan Makalah Pertemuan Ilmiah Nasional II Perhimpunan Dokter Spesialis Saraf Indonesia 51-66 : Airlangga University Press

Calder, P. C,(2006) n-3 Polyunsaturated Fatty Acids, Inflammation and Inflammatory Diseases Vol. 83, hal. 1505S-1519S : American Journal of Clinical Nutrition

Khotib, J., dan Zulkarnain, B., S,(2007) Penggunaan Analgetika pada Berbagai Bidang Terapi hal. 82-94 : Proceeding Seminar Nasional Farmasi Klinik: Implementasi Pelayanan Kefarmasian dalam Tatanan Klinik dan Update Farmakoterapi

Köhr, G,(2007) NMDA Receptor Antagonists: Tools in Neuroscience with Promise for treating CNS Pathologies Vol. 581. No. 1, hal.1-2 : Journal of Physiology





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2009-04
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  3. Characterization Of Carbamazepine- Hydroxypropyl-β-cyclodextrin Inclusion Complex In Solid State Obtained By Freeze-drying Process
  4. Formulasi Tablet Hisap Ekstrak Teh Hijau Berbasis Sorbitol Dengan Metode Granulasi Basah( Pengaruh Kadar Pengikat Methocel E-50 Terhadap Mutu Fisik Tablet )
  5. Pengaruh Sirkadian Pada Farmakokinetik Sulfametoksazol Oral Dengan Data Darah Kelinci
  6. Pengaruh Penambahan Kulit Pisang Cavendish (musa Cavendishii) Terhadap Kualitas Minyak Kelapa Murni Yang Mengalami Pemanasan Ulang
  7. Pengaruh Pemberian Antagonis Reseptor N-metil-d-aspartat (nmda) Mk-801 Terhadap Penurunan Sensasi Nyeri Inflamasi

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