UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 1 / Published : 2009-04

Order : 5, and page :22 - 27

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Original Article :

pengaruh sirkadian pada farmakokinetik sulfametoksazol oral dengan data darah kelinci

Author :

  1. Aniek Setiya B*1
  2. Toetik Ariyani*2
  3. Khoirotin Nisak*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The objective of this study was to determine the effect of circadian on pharmacokinetics variation of orally administered sulfamethoxazole in rabbit. Circadian variations of sulfamethoxazole pharmacokinetics were studied after a single oral administration sulfamethoxazole, 50 mg/kg bw, given at 09.00 a.m and 09.00 pm. Blood sample was taken from 0.25; 0.50; 1.00; 1.50; 2.00 ; 4.00 ; 6.00 ; 9.00; 12.00 ; 24.00 hours. Using spectrophotometer UV-VIS, the pharmacokinetics parameter was calculate for Area Under Curve (AUC), elimination rate constant (ke), and half life (t ½). From statistical analysis it could be seen that there were significant difference on AUC 09.00 am and 21.00 pm but not in elimination rate constant (ke) and halflife (t ½). The AUC was significantly smaller in the morning (2674.571±452.660 µg/ml.minutes) than in the nighttime (4536.532±1534.370 µg/ml.minutes) (p<0.05). The elimination rate constant (ke) was not  significantly increased in the morning (0.012±0.003/minutes) than in the night time (0.009±0.008/minutes) (p>0.05). The half-life (t1/2) was not significantly shorter in the morning (34.000±2.550 minutes) than the night time (58.200±0.840 minutes) (p>0.05). Overall, the results shows the difference characteristic of pharmacokinetics due to the circadian time.

Keyword :

Circadian, pharmacokinetics, sulfamethoxazole,


References :

Aronson, J K : Chappel, M J : Gofrey,, K R., Yew, M K Citation ,(1993) Modelling circadian variation in the pharmacokinetics of non-steroideal anti-inflamatory drugs 45(4): 357-61 : Eur J Clin Pharmacol;

Park S.I., Felipe C.R., Pinheiro-Machado P.G., Garcia R., Tedesco-Silva H.Jr., Medina-Pesta J.O.,(2007) Circadian and Time-Dependent Variability in Tacrolimus Pharmacokinetics Apr;21(2):191-7 : Fundam Clin Pharmacol. 2007

Shik, C.J. and Jung Jung E,(2001) Circadian Changes in Pharmacokinetics of Sulfamethoxazole Administered Orally to Rabbits Vol 24, pp. 338-341. : Arch Pharm Res

Srinivasu, P., Ramesh R.B., Madhusudhan R.Y., Rambhau D., ,(1998) Circadian Variations In The Pharmacokinetics Of Pentoxyfilline In Man vol. 50, no1, pp. 71-74 : Journal of pharmacy and pharmacology.





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2009-04
  1. Analisis Terhadap Faktor-faktor Yang Mempengaruhi Kepatuhan Penggunaan Obat Asma Inhalasi
  2. Influence Of Β-cyclodextrin As An Inclusion Complexing Agent For The Solubility Of Mefenamic Acid In Base Solution
  3. Characterization Of Carbamazepine- Hydroxypropyl-β-cyclodextrin Inclusion Complex In Solid State Obtained By Freeze-drying Process
  4. Formulasi Tablet Hisap Ekstrak Teh Hijau Berbasis Sorbitol Dengan Metode Granulasi Basah( Pengaruh Kadar Pengikat Methocel E-50 Terhadap Mutu Fisik Tablet )
  5. Pengaruh Sirkadian Pada Farmakokinetik Sulfametoksazol Oral Dengan Data Darah Kelinci
  6. Pengaruh Penambahan Kulit Pisang Cavendish (musa Cavendishii) Terhadap Kualitas Minyak Kelapa Murni Yang Mengalami Pemanasan Ulang
  7. Pengaruh Pemberian Antagonis Reseptor N-metil-d-aspartat (nmda) Mk-801 Terhadap Penurunan Sensasi Nyeri Inflamasi

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