UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 7 / No. 1 / Published : 2009-04

Order : 3, and page :13 - 16

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Original Article :

Characterization of carbamazepine- hydroxypropyl-β-cyclodextrin inclusion complex in solid state obtained by freeze-drying process

Author :

  1. Chrismawan Ardianto*1
  2. Soemartina S*2
  3. Dewi Isadiartuti*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

Complexation between Carbamazepine, an anticonvulsant drug used for the treatment of epilepsy, and hydroxypropyl-β-cyclodextrin (HPβCD) was studied in solid states. The inclusion complex was prepared in water solution of 1:1 molar and added with concentrated ammonium hydroxide to obtain true solution. The solid state of the inclusion complex was obtained by freeze-drying process. Complexation was characterized using infrared spectrophotometer, X-ray diffraction and Differential Thermal Analysis (DTA) compared to freeze-dried single compounds and their physical mixture. The result showed the different characteristic among inclusion complex, freeze-dried single compound and their physical mixture. It was assumed that there was an entrapment of the carbamazepine molecule into the molecule cavity of hydroxypropyl-β-cyclodextrin in the formation of the inclusion complex

Keyword :

characterization, inclusion complex, carbamazepine, hydroxypropyl-β-cyclodextrin,


References :

Isadiartuti, D., Suwaldi,(2005) = 16 (1), hal. 28-37 : Majalah Farmasi Indonesia

Jug, M., Lacan, M.B., Kwokal, A., Cizmek, B.C.,(2005) - 55, p. 223-236 : Acta Pharm.

Bekers, O., Uijtendaal, E.V., Beijnen, J.H., Bult, A., Underberg, W.J.M,(1991) - (17)11, p. 1503 – 1549. : Drug Dev. Ind. Pharm.

Meislich, H., Nechamkin, H., Sharefkin, J., Hademenos, G.J.,(1999) Schaum’s Outline of Theory and Problems of Organic Chemistry 3rd ed. P.230-255 : McGraw-Hill Companies Inc., USA





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2009-04
  1. Analisis Terhadap Faktor-faktor Yang Mempengaruhi Kepatuhan Penggunaan Obat Asma Inhalasi
  2. Influence Of Β-cyclodextrin As An Inclusion Complexing Agent For The Solubility Of Mefenamic Acid In Base Solution
  3. Characterization Of Carbamazepine- Hydroxypropyl-β-cyclodextrin Inclusion Complex In Solid State Obtained By Freeze-drying Process
  4. Formulasi Tablet Hisap Ekstrak Teh Hijau Berbasis Sorbitol Dengan Metode Granulasi Basah( Pengaruh Kadar Pengikat Methocel E-50 Terhadap Mutu Fisik Tablet )
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  7. Pengaruh Pemberian Antagonis Reseptor N-metil-d-aspartat (nmda) Mk-801 Terhadap Penurunan Sensasi Nyeri Inflamasi

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