Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)
ISSN 0852-1050
Vol. 7 / No. 1 / Published : 2009-04
Order : 2, and page :9 - 12
Related with : Scholar Yahoo! Bing
Original Article :
Influence of Β-cyclodextrin as an inclusion complexing agent for the solubility of mefenamic acid in base solution
Author :
- Febri Annuryanti*1
- Dewi Isadiartuti*2
- Soemartina*3
- Dosen Fakultas Farmasi
- Dosen Fakultas Farmasi
- Dosen Fakultas Farmasi
Abstract :
Mefenamic acid is a poorly water soluble non steroidal anti-inflammatory drug (NSAID). The solubility of mefenamic acid can be increased by forming inclusion complexes with β-cyclodextrin. Inclusion complexes can be performed when the drug molecules have a suitable size with β-cyclodextrin and it is influenced by the ionized/unionized form of drug molecules. The purpose of this study is to determine the effect of β-cyclodextrin for enhancing the solubility of mefenamic acid in base solution (pH 7,0: 8,0: 9,0: 10,0). This study is also considering the pKa value of mefenamic acid (pKa = 4.2) because it forms complexes with β-cyclodextrin in base solution. It is expected with the increasing of pH value, there will be more ionized molecule so it could influenced the performing of inclusion complexes. Phosphate buffer was used to make base solution of pH 7.0 and pH 8.0; and borate buffer was used for pH 9.0 and 10.0. Procedure to prepare the inclusion complexes was stirring or shaking β-cyclodextrin 2x10-3M solution with excessive mefenamic acid at temperature of 37±0.5oC. A supersaturated solution of mefenamic acid was formed after shaking the sample in waterbath shaker for 5 hours. Detection of inclusion complexes in solution using UV-Vis spectroscopy. The results showed that there were solubility increases in pH 7.0 and pH 8.0 27.07% and 26.57%, respectively. But there were no solubility increases showed in pH 9.0 and pH 10.0 because there were plenty of ionized mefenamic acid. It showed that pKa value affected the performing of inclusion complexes of mefenamic acid-β-cyclodextrin in base solution.
Keyword :
mefenamic acid; β-cyclodextrin; inclusion complex; base solution; solubility,
References :
Connors, K.A,(2000) Complex Formation, In : Alfonso R. Gennaro (Ed.), Remington : The Science and Practice of Pharmacy, 20 ed, p. 190-191 : Lippincott Williams&Wilkins Philadelphia
Lu, W.L., Zhang, Q., Zheng, L., Wang, H., Li, R.Y., Zhang, I., Shen, W.B., Tu, X.D.,(2004) Antipyretic, Analgesic and Anti-Infalammatory Activities of Ketoprofen β-Cyclodextrin Inclusion Complexes in Animal 27(10) p. 1515-1520 : Biol., Phar,. Bull.
Nalluri, B.N., Chowdary, K.P.R., Murthy, K.V.R., Hayman, A.R., Becket G,(2003) Physicochemical Characterization and Dissolution Properties of Nimesulide-Cyclodextrin Binary Systems 4(1), p.1-12 : AAPS Pharm. Sci. Tech
Reddy M.N., Rehana, T., Ramakrishna, S., Chowdary, K.P.R., Diwan, P.V,(2004) β-cyclodextrin Complexes of Celecoxib: Molecular Modelling, Characterization, and Dissolution Studies 6(1), p. 1-9 : AAPS Pharm. Sci. Tech.
Archive Article
| Cover Media | Content |
|---|---|
 Volume : 7 / No. : 1 / Pub. : 2009-04 |
|
