UNIVERSITAS AIRLANGGA



Detail Article

Majalah Farmasi Airlangga (Airlangga Journal of Pharmacy)

ISSN 0852-1050

Vol. 5 / No. 3 / Published : 2005-12

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Original Article :

Pengaruh posisi gugus metoksi para dan meta terhadap hasil sintesis asam para-metoksisinamat dan asam meta-metoksisinamat

Author :

  1. Juni Ekowati*1
  2. Suzana*2
  3. Tutuk Budiati*3
  1. Bagian Kimia Farmasi, Fakultas Farmasi Universitas Airlangga
  2. Bagian Kimia Farmasi, Fakultas Farmasi Universitas Airlangga
  3. Bagian Kimia Farmasi, Fakultas Farmasi Universitas Airlangga

Abstract :

The effect of position of methoxy group on synthesis of m-methoxycinnamic acid and p-methoxycinnamic acid through Knoevenagel reaction had been carried out. The synthesis was carried out by reacting the p-methoxybenzaldehyde and m-methoxybenzaldehyde with malonic acid in the present of pyridine. The mixture was stirred at 80C and monitored by TLC (hexane: ethyl acetate; 4:2;5 h), on silica gel (60 F254;0,2 mm). The m-methoxycinnamic acid (70%, m.p. 112oC), p-methoxycinnamic acid (54%, m.p. 170oC) were obtained as colourless crystal. The results showed that methoxy group at para position could decrease the Knoevenagel reaction because of steric effect and gave [+ M] effect, which could complicate nucleophylic addition in Knoevenagel reaction. On the other hand, methoxy group at meta position will give [-I] effect that enhanced the Knoevenagel reaction.

Keyword :

Knoevenagel reaction, [+M] effect, [-I] effect, methoxy group, synthesis, m-methoxycinnamic acid, p-methoxycinnamic acid,


References :

Tutuk Budiati,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Juni Ekowati,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Suzana,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

I.G.N. Astika,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Hadi Siswono,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Heru Wibowo,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Achmad Syahrani,(2003) Sintesis Turunan Sinamat sebagai Tirosinase Inhibitor, Project Grant Th. ke III Surabaya : Fakultas Farmasi Unair

Hadi Purwono,(2003)



Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2008-01
  1. Uji Efektifitas Sediaan Gel Antiseptik Tangan Yang Mengandung Etanol Dan Triklosan
  2. Pengembangan Formula Sediaan Gel Antiseptik Tangan Ekstrak Daun Sirih (piper Betle Linn)
  3. Pengaruh Posisi Gugus Metoksi Para Dan Meta Terhadap Hasil Sintesis Asam Para-metoksisinamat Dan Asam Meta-metoksisinamat
  4. Aktivitas Antimalaria Ekstrak Metanol, Fraksi Dan Isolat-isolat Dari Kulit Batang Cempedak (artocarpus Champeden, Spreng.)
  5. Aktivitas Antimalaria Ekstrak Diklorometana Kulit Batang Artocarpus Champeden Pada Kultur Plasmodium Falciparum
  6. Uji Toksisitas Akut Dan Subakut Ekstrak Etanol Dan Ekstrak Air Kulit Batang Artocarpus Champeden Spreng Dengan Parameter Histopatologi Hati Mencit
  7. Pengaruh Ekstrak Etanol Dan Ekstrak Air Kulit Batang Artocarpus Champeden Spreng Terhadap Kadar Enzim Sgpt Dan Sgot Mencit.

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