Majalah Ilmu Faal Indonesia
ISSN 0215-1995
Vol. 7 / No. 2 / Published : 2008-02
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Original Article :
Apoptosis: melalui mekanismenya menjadikan dasar strategi terapi
Author :
- Ngakan Made Rai Widjaja*1
- Laboratorium Ilmu Faal, Departemen Kedokteran Dasar Veteriner1
Fakultas Kedokteran Hewan, Universitas Airlangga Surabaya
Abstract :
The process of programmed cell death, or apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism. Apoptosis is generally characterized by distinct morphologiocal characteristics and energy - dependent biochemical mechanism. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone -dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human and animal conditions including neurodegenerative disease, ischemic damage, autoimmune disorders and many type of cancer. An increased understanding of the signaling pathways that govern the execution of apoptosis thus yield novel targets for therapeutic intervention in wide range of human and animal maladies. The aim of this article is to provide a general overview of current knowledge on the process of opoptosis including morphology, distinguishing apoptosis from necrosis, biochemistry and mechanism
Keyword :
apoptosis, programmed cell death, intrinsic/extrinsic pathway, granzyme A/B, perforin,
References :
Archive Article
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 Volume : 7 / No. : 2 / Pub. : 2008-02 |
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