UNIVERSITAS AIRLANGGA



Detail Article

Journal Orthopaedi and Traumatology Surabaya

ISSN 2460-8742

Vol. 7 / No. 1 / Published : 2018-04

Order : 4, and page :31 - 41

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Original Article :

The role of platelet-rich fibrin facilitates the healing of gastrocnemius muscle defect: a preliminary study on animal model

Author :

  1. Dwikora Novembri Utomo*1
  2. Kukuh Dwiputra Hernugrahanto*2
  1. Dosen Fakultas Kedokteran
  2. Mahasiswa Fakultas Kedokteran

Abstract :

Background: Scar formation has been a classical issue in the healing of skeletal muscle defect which will results in decrease of strength and function. Platelet-rich plasma (PRP) has been studied to enhance the healing of muscle defect. The disadvantages of it include the risk of immunologic reaction, time-consuming preparation, and lack of scaffold element. Platelet-rich fibrin (PRF) is a new generation of platelet concentrate that provides good source of growth factors and scaffold element necessary for the healing. This study is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model. Purpose: The goal is to provide a fondation of PRF preparation and implantation for the healing of experimental defect of gastrocnemius muscle in an animal model.  Methods: Animal Care and Use Committee, Airlangga University approved the study. Twenty New Zealand white rabbits were divided into two groups. In control group, a defect was created in the right gastrocnemius and no implantation was done. In study group, similar defect was created with implantation of PRF. Two and four weeks after surgery, the defect was examined immunohistochemically for the expression of Pax7 protein. Results: The implanted group showed higher IRS score in two and four weeks compared to the control group. Conclusion: The use of PRF facilitates the healing of muscle injury. This study will be used as a fondation for further study on PRF.

Keyword :

muscle defect, muscle healing, platelet-rich fibrin,


References :

Wong, S., Ning, A., Lee, C., & Feeley, B. T,(2015) Return to sport after muscle injury. (8): 168-175 : Current Reviews in Musculoskeletal Medicine

Menetrey J, kasemkijwattana C, Dac CS, Bosch P, Vogt M, Fu FH, Moreland MS, Huard J. ,(2000) Growth factors improve muscle healing in vivo. 82, 131-137 : J Bone Joint Surg [Br]

Sato K, Li Y, Foster W, Fukushima K, Badlani N, Adachi N, Usas A.,(2003) Improvement of Muscle Healing Through Enhancement of Regeneration and Prevention of Fibrosis. 28, 365-372 : Muscle Nerve





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2018-04
  1. Correlation Between Three Column Concept Classification And Internal Fixation Procedure Of Tibial Plateau Patients At Dr. Soetomo Hospital
  2. Correlation Between Harris Hip Score (hhs) And Body Mass Index (bmi) In Patients With Femoral Neck Fracture After Hemiarthroplasty
  3. Osteosarcoma Has Not Become Attention To Society Profile Of Osteosarcoma Patients At Dr. Soetomo General Hospital Surabaya “a Retrospective Study”
  4. The Role Of Platelet-rich Fibrin Facilitates The Healing Of Gastrocnemius Muscle Defect: A Preliminary Study On Animal Model
  5. The Effect Of Decellularization Technique On Collagen Type Ii And Matrices Porosity Of Cartilage Bovine Scaffold
  6. Long Term Functional Evaluation Autofibular Strut Graft In Case Of Fractures Neck Femur In Rsud Dr. Soetomo Surabaya
  7. Biomechanical Comparative Study Between Tension Band Wiring, Double Endo Button And Hook Plate For Acromioclavicular Joint Injury
  8. Orthopaedic Emergency Cases At Hasan Sadikin Hospital Bandung Caused By Traditional Bone Setter Practice
  9. Lower Leg Deformity Correction Using Ilizarov Device In Dr Soetomo General Hospital Surabaya: A Case Series

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