Planta Husada
ISSN 2338-7130
Vol. 2 / No. 2 / Published : 2014-10
Order : 1, and page :27 - 30
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Original Article :
Aktivitas antiviral influenza a subtipe h5n1dari ekstrak brucea javanica l.merr
Author :
- Neny Purwitasari*1
- Dosen Fakultas Farmasi
Abstract :
The outbreak of influenza A H5N1 subtype has raised a global concern on the future risk of a pandemic. Oseltamivir, the current antiinfluenza drug, could not meet the demand if there is a major outbreak. Thus, there is a need to find alternative treatment for influenza A. The objective of this study was to determine the antiviral activity of Brucea javanica extract against H5N1 influenza A virus, inoculated in embryonated chicken eggs. The antiviral activity was performed in hemagglutination assay. This is a method for tittering influenza viruses based on their ability to attach to molecules present on the surface of red blood cells. Serial concentrations of extract using in this study were tested on embryonated chicken eggs prior to the viral inhibition assay. Result showed that there is no death of chicken embryos after treated with the maximum concentration of the extract (1000 µg/ml) incubated for 72 hours. At the same concentration, B.javanica extract reduced 97.39% of H5N1 hemagglutinin titer. In conclusion, B.javanica has a potential to be developed as antiinfluenza, especially for inhibiting the initial step of viral infection.
Keyword :
H5N1Influenza A , Hemagglutination Assay, Brucea javanica,
References :
Kim, I.H., Suzuki, R., Hitotsuyanagi, Y, Takeya, K,(2004) Three novel quassinoids javanicolides A dan B, and javanicoside A from seeds of Brucea javanica. 59. 9985-9989 : Tetrahedron
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 Volume : 2 / No. : 2 / Pub. : 2014-10 |
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