UNIVERSITAS AIRLANGGA



Detail Article

Planta Husada

ISSN 2338-7130

Vol. 1 / No. 1 / Published : 2013-10

Order : 5, and page :13 - 16

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Original Article :

Hypoglycemic effect of andrographis paniculata nees and lagerstroemia speciosa extract combination

Author :

  1. Mulja Hadi S*1
  2. Sukardiman*2
  3. Awang Bilal S*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Mahasiswa Fakultas Farmasi

Abstract :

The aim of this present study is to determine the hypoglycemic effect of combined extract consists of alcoholic extract from herbs of Andrographis paniculata Nees and leaves of Lagerstroemia speciosa in alloxan-induced diabetic mice. Hypoglycemic effects were tested by treating mice alloxan-induced Balb/C in five groups of five animals for each group using  extract from herbs of Andrographis paniculata Nees, extract from leaves of Lagerstroemia speciosa and combined extract from herbs of Andrographis paniculata Nees and leaves of Lagerstroemia speciosa at doses of 28 mg/20 g  bodyweight. Obtained results were statistically compared with the results from group treated with CMC-Na 0.5% (control) using one way ANOVA followed by Tukey test to determine the significant changes in blood glucose level. Orally administration of 28 mg/20 g body wt. of Andrographis paniculata Nees extract exhibited blood glucose level reduction significantly on 7th days of treatment, on the other hand mices treated with Lagerstroemia speciosa extract and the combination from extract of Andrographis paniculata Nees and Lagerstroemia speciosa with all ratio for 7 days did not significantly reduce blood glucose level in alloxan-induced diabetic mice.

Keyword :

Andrographis paniculata, Lagerstroemia speciosa, Hypoglycemic Effect ,


References :

Akbar S,(2011) Andrographis paniculata: A Review of Pharmacological Activities and Clinical Effects New York : Alternative Medicine Review

Dipiro JT et al.,(2008) Pharmacotherapy: A Patophysiologic Approach, 7th Edition New York : McGraw Hill

Hossain MA et al.,(2007) Antidiabetic Activity of Andrographis paniculata - : Dhaka Univ. J. Pharm. Sci.

Klein G et al.,(2007) Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa - : Advance Access Publication

Saha BK et al.,(2009) Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action - : Bangladesh Journal Pharmacological 4

Tanquilut NR et al.,(2009) Hypoglycemic effect of Lagerstroemia speciosa(L.) Pers. on alloxan-induced diabetic mice - : Journal of Medicinal Plants Research





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2013-10
  1. Hypoglycemic Activity Of 96% Ethanolic Extract Of Andrographis Paniculata Nees. And Swietenia Mahagoni Jacq. Combination.
  2. Hypoglycemic Activity Herbal Tea Combination Of Andrographis Paniculata Herbs And Swietenia Mahagoni Seeds
  3. Hypoglycemic Activity Of Andrographis Paniculata Nees. And Lagerstroemia Speciosa L. Herbal Tea Combination
  4. ¬hypoglycemic Activity Of The Herbal Tea Combination Of Bitter Melon (momordica Charantia L.) And Lagerstroemia Speciosa Leaves In Alloxan-induced Mice
  5. Hypoglycemic Effect Of Andrographis Paniculata Nees And Lagerstroemia Speciosa Extract Combination

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