UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 2 / Published : 2012-12

Order : 4, and page :21 - 28

Related with : Scholar   Yahoo!   Bing

Original Article :

Pelepasan na-diklofenak sistem niosom span 20-kolesterol dalam basis gel hpmc

Author :

  1. Sherly Astuti Handayani*1
  2. Tutiek Purwanti*2
  3. Tristiana Erawati*3
  4. -*4
  5. -*5
  1. -
  2. Corresponding Author, Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Jln. Dharmawangsa Dalam, Surabaya
  3. -
  4. -
  5. -

Abstract :

The aim of this study was to determine the release of diclofenac sodium in niosome system (diclofenac sodium : Span 20 : cholesterol in 1:6:6 molar ratios) from HPMC 4000 gel base. This study, using two formulas; formula I gel was containing diclofenac sodium without niosome system and formula II gel was diclofenac sodium in niosome system. The results showed that diclofenac sodium in niosome system increased pH and spread-capacity of preparation; pH (6,57 ± 0,02) of formula II  higher than pH (5,94 ± 0,05) of formula I. Spread-capacity (7,6 ± 0,2 cm) of formula II was larger than spread-capacity (6,1 ± 0,1 cm) of formula I.  The release assay using diffusion cell covered with a cellophane membrane, phosphate buffer saline pH 7,4 ± 0,05 as test medium and temperature 32 ± 0,5°C for 6 hours. Flux release of diclofenac sodium from HPMC 4000 gel base in formula I and formula II were 155,6201 ± 4,9729 μg/cm2/minute½ and 49,0925 ± 0,8684 μg/cm2/minute½ respectively. The result was analyzed using Independent Sample T-test with α = 0,05. Research result revealed that diclofenac sodium release in niosome system from HPMC 4000 gel was lower than release of diclofenac sodium from formula without niosome system.

Keyword :

Niosome, Diclofenac, Span 20, HPMC, Drug Release,


References :

Barry, B.W,(1983) Dermatological Formulation Percutaneous Absorption New York : Marcel Dekker Inc.

Carter, SJ,(1986) Dispensing for Pharmaceutical Students - : Pitman Medical Publishing Co. Ltd

Kapoor, A., Gahoi, R., Kumar, D,(2011) In vitro drug release profile of Acyclovir from Niosomes formed with different Sorbitan esters - : Asian Journal of Pharmacy & Life Science

Katzung, BG,(2007) Basic and Clinical Pharmacology, 10th edition USA : The McGraw-Hill Companies, Inc

Tangri, P., and Khurana, S,(2011) Niosomes : formulation and evaluation - : International Journal of Biopharmaceutic





Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2012-12
  1. Daya Hambat Susu Hasil Fermentasi Lactobacillus Acidhopillus Terhadap Salmonella Thypimurium
  2. Pengaruh Perbandingan Obat-polimer Terhadap Karakteristik Fisik Dan Pelepasan Mikropartikel Ketoprofen-kitosan
  3. Karakterisasi Sediaan Dan Uji Pelepasan Natrium Diklofenak Dengan Sistem Mikroemulsi Dalam Basis Gel Hpc-m
  4. Pelepasan Na-diklofenak Sistem Niosom Span 20-kolesterol Dalam Basis Gel Hpmc
  5. Penetrasi Natrium Diklofenak Sistem Niosom Span 20 – Kolesterol Dalam Basis Gel Hpmc 4000

Information detail_jurnal.php/PHARM