UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 2 / Published : 2012-12

Order : 2, and page :7 - 11

Related with : Scholar   Yahoo!   Bing

Original Article :

Pengaruh perbandingan obat-polimer terhadap karakteristik fisik dan pelepasan mikropartikel ketoprofen-kitosan

Author :

  1. Retno Sari*1
  2. Desy Puspita R.A*2
  3. Agus Sjamsur Rijal*3
  4. -*4
  5. -*5
  1. Corresponding Author, Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University Jl. Dharmawangsa Dalam, Surabaya 60286 Indonesia
  2. -
  3. -
  4. -
  5. -

Abstract :

The aim of this research was to investigate the effect of ketoprofen amount on drug content and drug release profile of kitosan microparticles of ketoprofen. Microparticles was prepared by orifice-ionic gelation method with ketoprofen-chitosan ratio of 2:10; 3:10; and 4:10. Ketoprofen was dispersed in chitosan solution then the dispersion was dropped into tripolyphosphate solution. The obtained microparticles had have irregular shape after drying. The particle size of microparticles was larger by increasing initial drug amount. Efficiency encapsulation also increased as initial drug amount increased . In vitro- drug release from microparticles in phosphate buffer media pH 6,8 was slower than ketoprofen itself. Microparticles with the highest intial drug amount had the fastest release.

Keyword :

ketoprofen, microparticles, kitosan, sodium tripolyphosphate, orifice-ionic gelation,


References :

Agnihotri, S.A., Mallikarjuna, N.N., and Aminabhavi, T.M,(2004) Recent advances on chitosan-based micro- and nanoparticles in drug delivery - : Journal of Controlled Release

Burgess, D.J., and Hickey A.J,(2007) Microspheres Technology and Applications. In: J. Swarbrick, and J.C. Boylan (Eds.). USA : Informa Healthcare

Gunawan SG.,(2008) Farmakologi dan Terapi Jakarta : FKUI

Ko, J.A., Park, H.J., Hwang, S.J., Park, J.B., and Lee, J.S.,(2002) Preparation and characterization of chitosan microparticles intended for controlled drug delivery - : International Journal of Pharmaceutics

Sinha, V.R., Singla, A.K., Wadhawan, S., Kaushik, R., Kumria, R., Bansal, K., and Dhawan, S,(2004) Chitosan microspheres as a potential carrier for drugs - : International Journal of Pharmaceutics





Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2012-12
  1. Daya Hambat Susu Hasil Fermentasi Lactobacillus Acidhopillus Terhadap Salmonella Thypimurium
  2. Pengaruh Perbandingan Obat-polimer Terhadap Karakteristik Fisik Dan Pelepasan Mikropartikel Ketoprofen-kitosan
  3. Karakterisasi Sediaan Dan Uji Pelepasan Natrium Diklofenak Dengan Sistem Mikroemulsi Dalam Basis Gel Hpc-m
  4. Pelepasan Na-diklofenak Sistem Niosom Span 20-kolesterol Dalam Basis Gel Hpmc
  5. Penetrasi Natrium Diklofenak Sistem Niosom Span 20 – Kolesterol Dalam Basis Gel Hpmc 4000

Information detail_jurnal.php/PHARM